332872-68-1

Basic information

• Product Name: 2-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone
• Synonyms: 2-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone
• CAS NO: 332872-68-1
• Molecular Weight: 326.376
• Mol File: 332872-68-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(332872-68-1)
• EPA Substance Registry System: 2-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)-1-phenylethanone(332872-68-1)

Safety Data

• Hazardous Substances Data: 332872-68-1(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 69844-25-3 5-(2-methoxyphenyl)-1,3,4-oxadiazole-2-thiol 
• 579-75-9 2-Methoxybenzoic acid 
• 7466-54-8 2-methoxybenzoylhydrazine 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives

In present study, a series of new 2-(1,3,4-oxadiazol-2-ylthio)-1- phenylethanone derivatives (6a-6x) as potential focal adhesion kinase (FAK) inhibitors were synthesized. The bioassay assays demonstrated that compound 6i showed the most potent activity, which inhibited the growth of MCF-7 and A431 cell lines with IC50 values of 140 ± 10 nM and 10 ± 1 nM, respectively. Compound 6i also exhibited significant FAK inhibitory activity (IC50 = 20 ± 1 nM). Docking simulation was performed to position compound 6i into the active site of FAK to determine the probable binding model.