332884-35-2

Basic information

• Product Name: 2-AMINO-6-PYRIDINE CARBOXALDEHYDE
• Synonyms: 2-AMINO-6-PYRIDINE CARBOXALDEHYDE;2-Pyridinecarboxaldehyde,6-amino-(9CI);6-Amino-2-pyridinecarboxaldehyde;6-AMinopyridine-2-carbaldehyde;6-aMinopicolinaldehyde;2-Pyridinecarboxaldehyde, 6-aMino-
• CAS NO: 332884-35-2
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12
• Product Categories: PYRIDINE
• Mol File: 332884-35-2.mol

Chemical Properties

• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.264
• Vapor Pressure: 0.00616mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-6-PYRIDINE CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-PYRIDINE CARBOXALDEHYDE(332884-35-2)
• EPA Substance Registry System: 2-AMINO-6-PYRIDINE CARBOXALDEHYDE(332884-35-2)

Safety Data

• Hazardous Substances Data: 332884-35-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Amino-6-pyridine carboxaldehyde is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to form a variety of biologically active molecules. Its unique structure allows for the creation of compounds with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 2-amino-6-pyridine carboxaldehyde is employed as a building block in the development of new agrochemicals. Its reactivity and structural features contribute to the design of effective compounds for crop protection and enhancement of agricultural productivity.
Used in Dye Manufacturing:
2-AMINO-6-PYRIDINE CARBOXALDEHYDE is also used in the production of dyes, where its aromatic and conjugated system provides color and stability to the dyes. This makes it suitable for applications in various industries that require colorants, such as textiles, plastics, and printing inks.
Used in Organic Material Development:
2-Amino-6-pyridine carboxaldehyde has potential applications in the development of new organic materials due to its ability to participate in a range of chemical reactions. It can be incorporated into the design of materials with specific properties, such as conductivity or photoluminescence.
Used in Medicinal and Pharmaceutical Research:
2-AMINO-6-PYRIDINE CARBOXALDEHYDE is a subject of interest in medicinal and pharmaceutical research due to its potential biological activity. Studies are conducted to explore its interactions with biological systems, which may lead to the discovery of new drugs or therapeutic agents.

InChI:InChI=1/C6H6N2O/c7-6-3-1-2-5(4-9)8-6/h1-4H,(H2,7,8)

Upstream product

• 153140-22-8 2-tritylaminopyridine-6-carbaldehyde 
• 69142-64-9 ethyl 6-aminopicolinate 
• 153140-21-7 Ethyl 6-tritylaminopicolinate 
• 23628-31-1 6-aminopicolinic acid 
• 1211530-61-8 6-amino-N-methoxy-N-methylpicolinamide 

Relevant articles and documents

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Synthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes

A series of 1,8-naphthyridine derivatives containing vinyl, 2-(2-acetylamino-pyridine-6-ethylene)-4-methyl-7-acetylamino-1,8-naphthyridine (L1), 2-(2-acetylamino-pyridine-6-ethylene)-1,8-naphthyridine (L 2), 2-(2-acetylamino-pyridinyl-6-ethylene)-4-methyl-7-hydroxyl-1,8- naphthyridine (L3), 2-(2-diacetylamino-pyridinyl-3-ethylene)-7- diacetylamino-1,8-naphthyridine (L4), and 7-(2-diacetylamino- pyridinyl-3-ethylene)-4′-acetyl-pyrrolo[1′,5′-a]-1, 8-naphthyridine (L5), as well as complexes [CuL1(PCy 3)](BF4)2 (1) (PCy3 = tricyclohexylphosphine), [Cu2L1(PPh3) 4](BF4)2 (2) (PPh3 = triphenylphosphine), [Cu2L1(dppm)](BF4) 2 (3) (dppm = bis(diphenylphosphino)methane), and [Cu 2(L1)(dcpm)][BF4]2 (4) (dcpm = bis(dicyclohexylphosphino)methane, were synthesized. All these compounds, except for L1 and L2, were characterized by single crystal X-ray diffraction analysis, and a comprehensive study of their spectroscopic properties involving experimental theoretical studies is presented. We found an intramolecular 1,3-hydrogen transfer during the formation of L3 and L4, which in the case of the latter plays an important role in the 1,5-dipolar cyclization of L5. The spectral changes that originate from an intramolecular charge transfer (ICT) in the form of a πpy→π*napy transition can be tuned through acid/base-controlled switching for L1-L3. A photoinduced isomerization for L1-L3, 1, and 2 having flexible structures was observed under 365 nm light irradiation. Quantum chemical calculations revealed that the dinuclear complexes with structural asymmetry exhibit different metal-to-ligand charge-transfer transitions.

Efficient synthesis of new polyfunctionalized thiadiazaacenaphthylenes from imidazo[1,2-a]pyridines

New heterocycles containing sulfur and nitrogen with an azaindolizine moiety were synthesized. The imidazo[1,2-a]pyridine-2,5-dicarboxylates (9a, b, 10a, b) and 5-formylimidazo[1,2-a]pyridine-2-carboxylates (17a, b) treated with ethyl thioglycolate and lithium hydroxide underwent ring closure yielding the multifunctional[2,3,3]cyclazines (13) and (18). Under similar conditions, the imidazo[1,2-a]pyridinecarbaldehydes (22a, b) and (29a, b) were converted into the linearly cyclized compounds thieno[3,2-b]imidazo[1,2-a]pyridines (23, 31) and a peri annulated product thiadiazaacenaphthylene (30).