69142-64-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Aminopyridine-2-carboxylic acid ethyl ester is used as a key intermediate for the synthesis of various pharmaceutical compounds, such as anti-inflammatory agents, antitumor agents, and anti-hypertensive medications. Its chemical properties and structure enable the development of effective and targeted drug therapies.
Used in Organic Synthesis:
6-Aminopyridine-2-carboxylic acid ethyl ester is utilized as a versatile building block in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications.
Used in Laboratory Research:
6-Aminopyridine-2-carboxylic acid ethyl ester is employed as a valuable component in laboratory research, where its unique properties can be explored and harnessed for the advancement of scientific knowledge and the development of new technologies.
Used in Industrial Manufacturing Processes:
6-Aminopyridine-2-carboxylic acid ethyl ester is incorporated into industrial manufacturing processes, where its versatility and chemical properties contribute to the production of various products and materials.

InChI:InChI=1/C8H10N2O2/c1-2-12-8(11)6-4-3-5-7(9)10-6/h3-5H,2H2,1H3,(H2,9,10)

Upstream product

• 26893-72-1 6-acetamido-picolinic acid 
• 64-17-5 ethanol 
• 504-29-0 2-aminopyridine 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 23628-31-1 6-aminopicolinic acid 
• 1824-81-3 2-Amino-6-methylpyridine 
• 5327-33-3 2-acetylamino-6-methylpyridine 
• 258497-21-1 6-[(tert-butoxycarbonyl)amino]-2-pyridinecarboxylic acid 

Downstream Products

• 177485-39-1 ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate 
• 79651-64-2 (6-Amino-pyridin-2-yl)-methanol 
• 203321-83-9 tert-butyl 6-(hydroxymethyl)-2-pyridinylcarbamate 
• 383672-30-8 ethyl 6-[[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-5-(2,3-dimethoxyphenyl)-7-chloro-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]amino]-2-pyridinecarboxylate 
• 153140-24-0 Diethyl (6-tritylamino-2-pyridyl)methylmalonate 
• 153140-23-9 Ethyl 2-ethoxycarbonyl-3-(6-tritylamino-2-pyridyl)acrylate 
• 153140-25-1 2-Tritylamino-6-(2-carboxyethyl)pyridine 
• 153140-16-0 2-amino-6-(2-carboxyethyl)-pyridine 
• 167884-17-5 5-hydroxymethylimidazo[1,2-a]pyridine 
• 372147-66-5 (Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-5-yl)propenoate 
• 429690-42-6 ethyl 3-bromoimidazo[1,2-a]pyridine-5-carboxylate 
• 429690-44-8 3-nitroimidazo[1,2-a]pyridine-5-carbaldehyde 
• 429690-43-7 3-bromoimidazo[1,2-a]pyridine-5-carbaldehyde 
• 332884-35-2 2-aminopyridine-6-carbaldehyde 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Efficient synthesis of tert-Butyl (6-Formylpyridin-2-yl)carbamic acid

We have developed an efficient four-step synthesis of tert-butyl (6-formylpyridin-2-yl)carbamic acid (1) in 80% overall yield using inexpensive starting material and reagents and no air-sensitive reagents. Column chromatography was not required for purification of the intermediates or the final product.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

3-SUBSTITUED IMIDAZO (4, 5-B) PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e

Synthesis and crystallographic analysis of short pyridine-based oligoamides as DNA-targeting supramolecular binders

In this study, the synthesis of the pyridine peptides 1-4, formed from amino-picolinic acid, and pyridine peptide 5, made from coupling of a mono-protected pyridine diamine to a mono-protected pyridine dicarboxylic acid and the X-ray crystallographic structures of 1 and 5 are discussed, along with their supramolecular interactions in the solid state. The structure of these compounds showed that they possess concave appearance which can be employed to bind to nucleic acids through multiple hydrogen bonding, which would facilitate the formation of helical-based pyridine oligoamides as novel DNA-binding molecules. This was proven by carrying out DNA denaturation studies and ethidium displacement assay on 5, but, by using MTT assays, 5 was shown to be cytotoxic against drug-resistant chronic myeloid leukaemia K562 cell-line.

BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are sirtuin-modulating compounds of formula (II) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

BENZOXAZOLES, BENZTHIAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

CHROMENONE ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e

AZABENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for e