332902-34-8Relevant academic research and scientific papers
On the influence of chiral auxiliaries in the stereoselective cross-coupling reactions of titanium enolates and acetals
Baiget, Jessica,Cosp, Annabel,Gálvez, Erik,Gómez-Pinal, Loreto,Romea, Pedro,Urpí, Fèlix
, p. 5637 - 5644 (2008/09/21)
Titanium enolates from chiral N-propanoyl-1,3-thiazolidine-2-thiones containing bulky substituents at C4 turned out to be excellent platforms to get highly stereocontrolled cross-coupling reactions with acetals. Related oxazolidinethiones also afforded go
Synthesis of O-benzyl protected anti aldols through the cross-coupling reaction of dibenzyl acetals with a chiral titanium enolate
Cosp, Anabel,Larrosa, Igor,Vilasís, Irina,Romea, Pedro,Urpí, Fèix,Vilarrasa, Jaume
, p. 1109 - 1112 (2007/10/03)
Addition of the chiral titanium enolate arising from 1 to dibenzyl acetals gives access to anti-β-benzyloxy-α-methyl carboxylic adducts in good yields and with diastereomeric ratios up to 99:1. These adducts can be easily converted into a plethora of enantiopure protected derivatives.
Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals
Cosp, Annabel,Romea, Pedro,Talavera, Pere,Urpi, Felix,Vilarrasa, Jaume,Font-Bardia, Merce,Solans, Xavier
, p. 615 - 617 (2007/10/03)
(Matrix presented) High stereoselectivities (up to 98% de) have been achieved for the Lewis acid-mediated cross-coupling reaction of dimethyl acetals to a chiral 1,3-thiazolidine-2-thione-derived titanium enolate. The reaction affords enantiopure anti α-m
