102831-92-5

Basic information

• Product Name: (S)-4-Isopropyl-3-propionyl-1,3-oxazolidine-2-thione
• Synonyms: (S)-4-ISOPROPYL-3-PROPIONYL-1,3-OXAZOLIDINE-2-THIONE;S- 4-(1-Methylethyl)-3-(1-oxopropyl)-2-Thiazolidinethione;(S)-4-Isopropyl-3-(1-oxopropyl)-2-thiazolidinethione,99%e.e.;(S)-4-Isopropyl-3-(1-oxopropyl)-2-thiazolidinethione
• CAS NO: 102831-92-5
• Molecular Formula: C₉H₁₅NOS₂
• Molecular Weight: 201.29
• Mol File: 102831-92-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 252.242 °C at 760 mmHg
• Flash Point: 106.353 °C
• Appearance: /
• Density: 1.148 g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.534
• PKA: -1.82±0.40(Predicted)
• CAS DataBase Reference: (S)-4-Isopropyl-3-propionyl-1,3-oxazolidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Isopropyl-3-propionyl-1,3-oxazolidine-2-thione(102831-92-5)
• EPA Substance Registry System: (S)-4-Isopropyl-3-propionyl-1,3-oxazolidine-2-thione(102831-92-5)

Safety Data

• Hazardous Substances Data: 102831-92-5(Hazardous Substances Data)

Usage

General Description

"(S)-4-Isopropyl-3-propionyl-1,3-oxazolidine-2-thione" is a chemical compound that is categorized under the oxazolidines, a class of organic compounds. This molecule is characterized by its oxazolidine core, a type of heterocyclic ring that consists of three carbon atoms, one nitrogen atom, and an oxygen atom. This specific compound has an isopropyl and a propionyl functional group attached to it, as suggested by its name. The prefix “(S)” indicates that it is the 'S' or 'Sinister' enantiomer, meaning it rotates plane polarized light counterclockwise. However, the practical use, reactivity, toxicity, and other chemical properties of this compound are not widely documented in the literature.

InChI:InChI=1/C9H15NO2S/c1-4-8(11)10-7(6(2)3)5-12-9(10)13/h6-7H,4-5H2,1-3H3/t7-/m1/s1

Upstream product

• 76186-04-4 (S)-4-isopropylthiazolidine-2-thione 
• 802294-64-0 propionic acid 
• 110199-16-1 4(R)-isopropyl-1,3-thiazolidine-2-thione 
• 123-62-6 propionic acid anhydride 
• 79-03-8 propionyl chloride 
• 2026-48-4 (S)-valinol 

Downstream Products

• 933452-83-6 (3S,4R)-3-methyl-4-phenyl-azetidin-2-one 
• 262614-91-5 C₄₅H₆₁NO₇S₂Si 
• 1378889-75-8 C₃₀H₄₃NO₃S₂Si 
• 332902-42-8 (4S)-N-[(2R,3S,4E)-2,4-dimethyl-3-methoxy-5-phenyl-4-pentenoyl]-4-isopropyl-1,3-thiazolidine-2-thione 
• 76186-04-4 (S)-4-isopropylthiazolidine-2-thione 

Relevant articles and documents

A acylation of the synthesis method of sulfur on behalf of the oxazolidone

The invention discloses a method for acylation of the synthesis method of sulfur on behalf of the oxazolidone. Synthesis method of the invention, comprising the following steps: in the non-protic organic solvent, the compound III and under the action of a

Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives

A series of simple structural 1,3-thiazolidine-2-thione derivatives with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcohols via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR analysis indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, 4-isopropyl-N-propionylthiazoldine-2-thione shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 g/mL and 6.5 g/mL, respectively, and 4-isobutyl-N-propionylthiazoldine-2-thione shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 g/mL, 12.1 g/mL, and 11.0 g/mL, respectively. GRAPHICAL ABSTRACT.

Enantioselective synthesis of structurally intricate and complementary polyoxygenated building blocks of spongistatin 1 (altohyrtin a)

Enantioselective approaches to the construction of four complex building blocks of the structurally intricate marine macrolide known as spongistatin 1 are presented. The first phase of the synthetic effort relies on a practical approach to a desymmetrized, enantiomerically pure spiroketal ring system incorporating rings A and B. Concurrently, the C17-C28 subunit, which houses one-fifth of the stereogenic centers of the target in the form of rings C and D, was assembled via a composite of stereocontrolled aldol condensations. Once arrival at the entire C1-C28 sector had been realized, routes were devised to provide two additional highly functionalized sectors consisting of C29-C44 and C38-C51. A series of subsequent transformations including cyclization of the E ring and hydroboration to afford the B-alkyl intermediate for the key Suzuki coupling to append the side chain took advantage of efficient stereocontrol. Ultimately, complete assembly and functionalization of the western EF sector of spongistatin was thwarted by an inoperative Suzuki coupling step intended to join the side chain to the C29-C44 sector, and later because of complications due to protecting groups, which precluded the complete elaboration of the late stage C29-C51 intermediate.