332903-75-0

Upstream product

• 87-65-0 2,6-Dichlorophenol 
• 79-04-9 chloroacetyl chloride 
• 332903-73-8 N-(2',6'-Dichlorophenyl)-4-methylaniline 
• 1002502-24-0 2-(2,6-dichloro-phenoxy)-N-p-tolyl-acetamide 
• 16634-82-5 N-(p-tolyl)-2-chloroacetamide 

Relevant academic research and scientific papers

Process for phenylacetic acid derivatives

A process for the production of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula II wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of Formula I are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase II.

Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds

Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-(N-arylamino)-phenylacetic acids. Two novel approaches were explored for the construction of diarylamine and N-aryl oxindole core structures, in addition to Buchwald-arylamination and Smiles rearrangement. Condensation of anilines with 2-oxo-cyclohexylidene-acetic acid derivatives and subsequent dehydrogenation is a new and viable method for the preparation of N-aryl oxindoles. Graphical Abstract.