332904-91-3Relevant academic research and scientific papers
Amine-catalyzed direct asymmetric Mannich-type reactions
Notz, Wolfgang,Sakthivel, Kandasamy,Bui, Tommy,Zhong, Guofu,Barbas III, Carlos F.
, p. 199 - 201 (2001)
Three chiral cyclic secondary amines are shown to be catalysts for the direct asymmetric Mannich-type reaction of acetone with a variety of preformed aldimines derived from o-anisidine. A simple one-pot three-component reaction procedure consisting of aldehyde, acetone, p-anisidine and an amine catalyst provides the corresponding β-amino ketones with 50-89% ee under very mild conditions.
Amino acid catalyzed direct asymmetric aldol reactions: A bioorganic approach to catalytic asymmetric carbon-carbon bond-forming reactions
Sakthivel,Notz,Bui,Barbas III
, p. 5260 - 5267 (2007/10/03)
Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes and unmodified ketones together with commercially available chiral cyclic secondary amines as catalysts. Structure-based catalyst screening identified L-proline a
