332935-12-3Relevant academic research and scientific papers
Synthesis of hydroxylactams and esters derived from thalidomide and their antitumor activities
Sun, Guanglong,Liu, Xiangchao,Zhou, Heng,Liu, Zenglu,Mao, Zhenmin
, p. 1337 - 1342 (2014/06/09)
A novel and convenient route for the synthesis of a series of thalidomide derivatives is described. Compound 2 was cyclized with different amines under alkaline condition to obtain 4-nitro substituted phthalimidines 3a-d. Hydroxylactams 4a-d were produced via bromination and hydroxylation. Different acyl chlorides were reacted with hydroxylactams to provide the desired esters 5a-d. All compounds were evaluated by MTT assay for their inhibitory activities against HCT-116, MG-63, MCF-7, HUVEC and HMVEC cell lines in vitro. Most of them showed no obvious cytotoxic effect on normal human cells, compounds 4a-d, 5a2, 5a4, 5a5, 5b2, 5c2 and 5d2 exhibited potent antitumor activities, among which compounds 5a2 and 5b2 were more effective than 5-FU.
Reactivity of N-Benzyl-3-nitrophthalimide: A facile access to isoindolo[1,2-d][3,5]benzothiazocine derivatives
Chihab-Eddine,Daich,Jilale,Decroix
, p. 1543 - 1548 (2007/10/03)
A functionalized isoindolo[1,2-d][3,5]benzothiazocine 2B has been synthesized in three steps from the nitro-imide derivative 5. The key step of this sequence was the cyclization of the thioglycolic acid derivative 9 under acidic conditions. An evaluation
