33322-20-2

Usage

Usage

Production of pharmaceutical drugs, fragrances, and flavorings

Physical properties

Yellow, oily liquid with a strong odor

Hazards

Highly flammable, toxic, mutagen, potential carcinogen

Safety measures

Handle with caution and use appropriate safety measures

Research

Studied for potential anti-cancer properties and applications in cancer treatment

InChI:InChI=1/C7H7NO3/c1-6(8(9)10)5-7-3-2-4-11-7/h2-5H,1H3

Upstream product

• 79-24-3 Nitroethane 
• 617-89-0 furan-2-ylmethanamine 
• 98-01-1 furfural 

Downstream Products

• 1442645-59-1 C₁₈H₁₇NO₃ 
• 1449522-78-4 4-furan-2-yl-5-methyl-2-phenyl-1H-imidazole 
• 1454253-89-4 C₁₄H₁₁BrN₂O 
• 1454253-79-2 C₁₄H₁₂N₂O 
• 1454253-81-6 C₁₄H₁₁N₃O₃ 
• 1519057-40-9 3-(furan-2-yl)-2,6,6-trimethyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 
• 1519057-80-7 3-(furan-2-yl)-2-methyl-1-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 
• 211096-32-1 3,5-dimethyl-4-(furan-2-yl)isoxazole 
• 1600521-10-5 1-(4-(furan-2-yl)-2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethanone 
• 1314297-43-2 4-(furan-2-yl)-5-methyl-3-(phenylsulfonyl)-1H-pyrazole 
• 1320232-32-3 C₁₈H₁₇NO₃ 

Relevant academic research and scientific papers

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.

Synthesis of sulfonate derivatives of 4-heteryl-isoxazoles

Synthesis procedure of 3,5-dimethyl-4-heteryl-isoxazoles by reaction between heterocyclic aldehydes and nitroethane in the presence of base was developed. Sulfochlorination of the resulting compounds was studied.

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

Ambiphilic dual activation role of a task-specific ionic liquid: 2-hydroxyethylammonium formate as a recyclable promoter and medium for the green synthesis of β-nitrostyrenes

A cost-effective task-specific ionic liquid, 2-hydroxyethylammonium formate, efficiently promotes the condensation of nitroalkanes with various aldehydes to produce β-nitrostyrenes in high to excellent yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions. In addition, a novel mechanism has been proposed invoking ambiphilic dual activation influence of the ionic liquid.