3333-07-1Relevant academic research and scientific papers
Copper-catalyzed coupling of N -tosylhydrazones with amines: Synthesis of fluorene derivatives
Aziz, Jessy,Frison, Gilles,Gmez, Montserrat,Brion, Jean-Daniel,Hamze, Abdallah,Alami, Mouad
, p. 4498 - 4503 (2015/02/19)
An original formation of one C-N bond and one C-C bond on the same carbenic center has been developed. This approach involves a copper-catalyzed cross-coupling reaction between 2'-bromo-biaryl-N-tosylhydrazones and different amines leading to 9H-fluoren-9-amine derivatives. This reaction proceeds under mild conditions in glycerol, an inexpensive and environmentally friendly solvent, without adding any external ligand.
Transition Metal-Catalyzed C-H Amination Using Unactivated Amines
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Page/Page column 3; 27, (2011/09/20)
One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containing catalyst, thereby forming a product with a covalent bond between the carbon of the reactive C—H bond and the nitrogen of the reactive N—H bond.
