33330-91-5Relevant academic research and scientific papers
1-(p-Carbamoylphenyl)-3,3-dimethyltriazene, an Antitumour Agent
Bullerwell, Wendy L.,MacGillivray, Leonard R.,Zaworotko, Michael J.,Vaughan, Keith,Wilman, Derry E. V.
, p. 2624 - 2627 (1995)
In the crystal structure of the title compound, 4-(3,3-dimethyl-1-triazeno)benzamide, C9H12N4O, (2), the N=N double bond is 0.030 Angstroem shorter than the N-N single bond , but both bonds are shorter than an isolated N-N single bond suggesting that there is double-bond character in each N-N bond, although it is unequally distributed.The molecule adopts a trans geometry around the N=N bond, but there is a significant deviation from planarity between the benzene ring and the plane of the triazene moiety.Compound (2) forms chains in the solid state in which the molecules are linked by C=O...H-N hydrogen bonds between carbamoyl groups.These chains are cross-linked into sheets by hydrogen bonding between the second N-H moiety and triazene units in adjacent chains.
Tumor Inhibitory Triazenes. 3. Dealkylation within an Homologous Series and Its Relation to Antitumor Activity
Wilman, Derry E. V.,Cox, Peter J.,Goddard, Phyllis M.,Hart, Leigh I.,Merai, Kanti,Newell, David R.
, p. 870 - 874 (2007/10/02)
The in vivo antitumor activity and in vitro metabolic dealkylation have been measured for an homologous series of 3-alkyl-1-(4-carbamoylphenyl)-3-methyltriazenes and have been compared with their partition coefficients.This investigation has shown that th
