333310-33-1Relevant academic research and scientific papers
Tandem dienyne cross-metathesis/ring-closing metathesis
Smulik, Jason A.,Diver, Steven T.
, p. 171 - 174 (2001)
Tandem enyne cross-metathesis/ring-closing metathesis between terminal alkynes and 1,5-hexadiene has been demonstrated using the 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium benzylidene complex. Synthesis of 2-substituted 1,3-cyclohex
Synthesis of 1,3-cyclohexadienes by tandem diene-alkyne metathesis: Improved procedure
Middleton, Mark D.,Diver, Steven T.
, p. 4039 - 4043 (2007/10/03)
A practical synthesis of 2-substituted 1,3-cyclohexadienes by the cross enyne metathesis between alkynes and 1,5-hexadiene is reported. The isolation of the 1,3-cyclohexadienes has been hampered by the formation of an inseparable triene by-product. The use of a second consecutive cross alkene metathesis to give water-soluble products allowed removal of this by-product. Using this one-pot procedure, a synthesis of cyclohexadienes from simple starting materials was developed. The procedure was used in a three-step synthesis of a functionalized tetrahydroquinoline using Pd(II)-catalyzed chloroacetoxylation (B?ckvall reaction) for cyclohexadiene functionalization.
