2174-59-6

Basic information

• Product Name: 5-DEMETHYLNOBILETIN
• Synonyms: 5-DEMETHYLNOBILETIN;5-DIMETHYLNOBILETIN;2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one
• CAS NO: 2174-59-6
• Molecular Formula: C₂₀H₂₀O₈
• Molecular Weight: 388.37
• Mol File: 2174-59-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 145-146℃
• Boiling Point: 601.4°Cat760mmHg
• Flash Point: 213.9°C
• Appearance: /
• Density: 1.304±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 4.68E-15mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: 2-8°C
• PKA: 6.81±0.40(Predicted)
• CAS DataBase Reference: 5-DEMETHYLNOBILETIN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-DEMETHYLNOBILETIN(2174-59-6)
• EPA Substance Registry System: 5-DEMETHYLNOBILETIN(2174-59-6)

Safety Data

• Hazardous Substances Data: 2174-59-6(Hazardous Substances Data)

Usage

Uses

2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one is used in the treatment of neurodegenerative and metabolic disorders

InChI:InChI=1/C20H20O8/c1-23-12-7-6-10(8-14(12)24-2)13-9-11(21)15-16(22)18(25-3)20(27-5)19(26-4)17(15)28-13/h6-9,22H,1-5H3

Upstream product

• 520-34-3 diosmetin 
• 520-33-2 hesperetin 
• 29080-58-8 5-hydroxy-3',4',7-trimethoxyflavone 
• 520-26-3 hesperidin 
• 124-41-4 sodium methylate 
• 10544-05-5 2-(3,4-dimethoxy-phenyl)-7-hydroxy-5-methoxy-chromen-4-one 
• 520-27-4 diosmin 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 56002-80-3 2-acetoxy-1,3,4,5-tetramethoxybenzene 
• 53887-77-7 2-hydroxy-3,4,5,6-tetramethoxybenzene 
• 86475-21-0 2,3,4,5-tetramethoxyphenylformate 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 19676-64-3 2,3,4-trimethoxyphenol 
• 65884-12-0 2,3,4,5-tetramethoxybenzaldehyde 

Downstream Products

• 2192-25-8 5-hydroxy-3',4',6,7,8-pentamethoxyflavone 
• 478-01-3 nobiletin 

Relevant articles and documents

Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation

This study aimed to reveal the interaction and inhibitory mechanisms of tangeretin (TAN), nobiletin (NBT), and their acidic hydroxylated forms, 5-demethyltangeretin (5-DT) and 5-demethylnobiletin (5-DN) on porcine pancreatic lipase (PPL) using spectroscop

5-Demethylnobiletin and 5-Acetoxy-6,7,8,3′,4′-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice

Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones (HPMFs), such as nobiletin (Nob) and 5-demethylnobiletin (5-OH-Nob), are unique flavonoids that are found exclusively in citrus peels. Nobiletin has been shown to suppress adipogenesis in vit

Hydroxylated polymethoxylated flavone and preparation method thereof

The invention provides hydroxylated polymethoxylated flavone and a preparation method thereof. The chemical structure of a compound is shown as a formula (I). The method comprises the following steps: synthesizing an intermediate product 2a by using an in