333353-60-9

Upstream product

• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 100-46-9 benzylamine 
• 4412-96-8 3-methylfuran-2-carboxylic acid 

Downstream Products

• 349112-47-6 N-benzyl-N-[(3-methyl-2-furyl)methyl]amine 
• 1105691-53-9 N-benzyl-5-bromo-3-methylfuran-2-carboxamide 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

Intra-molecular Diels-Alder reactions of citraconamic acids from furfurylamines and citraconic anhydride: Effects of substitution in the furan ring on regioselectivity

Regioselectivity in the intra-molecular Diels-Alder (IMDA) reaction of furfurylcitraconamic acids derived from N-benzylfurfurylamines and citraconic anhydride can be controlled by substituents located in the furan ring and by reaction conditions. Reactions conducted under kinetic conditions resulted in cycloaddition products having methyl and aminomethylene substituent in 1,3-relationship whereas under thermodynamic conditions, excepting in the case of the 3-methylsulfanyl group, the products rearranged to more stable cycloadducts in which the substituents are in 1,2-relationship. Product formation can be explained on the basis of frontier orbital interactions and steric considerations.