6141-57-7Relevant articles and documents
Synthetic studies on pseudolaric acid B: Enantioselective synthesis of C4,C10-di-epi-trans-fused [5-7]-bicyclic skeleton
Guo, Rui,Zhai, Hongbin,Li, Yun
supporting information, p. 1400 - 1402 (2020/10/07)
Studies on the synthesis of antifungal and anticancer natural product, pseudolaric acid B, have led to the enantioselective synthesis of di-epi-trans-fused [5–7]-bicyclic core skeleton. The synthesis was achieved in 10 linear steps, which features the Sharpless asymmetric epoxidation, cyanide-opening reaction of epoxide, and intramolecular [5 + 2] cycloaddition reaction as the key transformations. The stereochemistry was determined by the X-ray crystallographic analysis.
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors
Lee, Sunkyung,Kim, Taemi,Lee, Byung Ho,Yoo, Sung-eun,Lee, Kyunghee,Yi, Kyu Yang
, p. 1291 - 1295 (2008/02/02)
The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 0.02 μM) that match those of 3-unsubstituted derivatives.
VOLATILE CONSTITUENTS OF CLAUSENA WILLDENOVII: STRUCTURES OF THE FURANOTERPENES α-CLAUSENAN, DICLAUSENAN A AND DICLAUSENAN B
Subba Rao, G. S. R.,Ravindranath, Bhagavatula,Sashi Kumar, V. P.
, p. 399 - 402 (2007/10/02)
Four furanoid terpenic compounds, α-clausenan, rosefuran (γ-clausenan) and diclausenans A and B, were isolated from the essential oil of the leaves of Clausena willdenovii.Their structures were determined by chemical and spectral data.The occurence of a high concentration of rosefuran is noteworthy.Selenium dioxide oxidation of diclausenan gave an unusual product, identified as an epoxy-dicarbonyl compound. - Keywords: Clausena willdenovii; Rutaceae; furanoterpenes; α-clausenan; γ-clausenan (rosefuran); diclausenans A and B.
