333383-90-7

Upstream product

• 333383-77-0 N-(4-bromo-phenyl)-4-methyl-N-(3-oxo-propyl)-benzenesulfonamide 
• 32857-48-0 N-(4-bromophenyl)-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 5332-25-2 6-bromoquinoline 

Relevant academic research and scientific papers

Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate

Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production. General formula A General formula B General formula C

A practical route to quinolines from anilines

A practical route to quinoline from anilines through acid-mediated cyclization of 3-(N-aryl-N-sulfonylamino)propionaldehydes has been developed. Treatment of the cyclization products, dihydroquinoline intermediates with KOH in DMSO leads to substituted quinolines.