3334-98-3

Upstream product

• 126-81-8 dimedone 
• 109-73-9 N-butylamine 

Downstream Products

• 105787-58-4 E,Z-N,N'-<3,3'-Oxybis(5,5-dimethyl-2-cyclohexen-1-yliden)>bis(butylammonium)-bis(trifluormethansulfonat) 
• 105787-54-0 E,E-N,N'-<3,3'-Oxybis(5,5-dimethyl-2-cyclohexen-1-yliden)>bis(butylammonium)-bis(trifluormethansulfonat) 
• 105787-56-2 Z,Z-N,N'-<3,3'-Oxybis(5,5-dimethyl-2-cyclohexen-1-yliden)>bis(butylammonium)-bis(trifluormethansulfonat) 
• 105787-42-6 Z-N-<5,5-Dimethyl-3-(trifluormethylsulfonyloxy)-2-cyclohexen-1-yliden>butylammonium-trifluormethansulfonat 
• 105787-40-4 E-N-<5,5-Dimethyl-3-(trifluormethylsulfonyloxy)-2-cyclohexen-1-yliden>butylammonium-trifluormethansulfonat 
• 606924-44-1 N-(1-butyl-6,6-dimethyl-2,4-dioxo-3-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-indol-3-yl)-benzamide 
• 1144029-18-4 2-amino-1-butyl-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1144029-20-8 2-amino-1-butyl-4-(2-chlorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1144029-19-5 2-amino-1-butyl-4-(3,4-dichlorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1338725-69-1 1-butyl-4-(3-chlorophenyl)-2-(4-chlororphenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1357791-01-5 4-butyl-9-(4-hydroxyphenyl)-6,6-dimethyl-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione 
• 1357791-04-8 9-(4-bromophenyl)-4-butyl-6,6-dimethyl-5,6,7,9-tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione 
• 1431986-11-6 3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-6,6-dimethyl-1,2-diphenyl-6,7-dihydro-1H-indol-4(5H)-one 
• 1423126-14-0 2-(4-tert-butylphenyl)-9-chloro-4,5-dihydro-4,4-dimethylpyrrolo[2,3,4-kl]acridin-1(2H)-one 

Relevant academic research and scientific papers

β-Enaminones over recyclable nano-CoFe2O4: a highly efficient solvent-free green protocol

Abstract: β-Enaminone and its derivatives have emerged among the finest bioactive intermediates. High yields of several β-enaminones (86–97%) are achieved through treatment of substituted aromatic and aliphatic amines with cyclic/acyclic 1,3-diketones, over the magnetically separable cobalt ferrite nanoparticles (CoFe2O4 NPs). The latter was prepared upon co-precipitation. Its purity, fine crystallinity, elemental distributions, morphology, magnetic features, and thermal stability were confirmed by Fourier transform infrared, X-ray diffraction, energy dispersive X-ray spectrometry, scanning electron microscopy, vibrating sample magnetometry, and thermal gravimetric analysis analyses. Thus, CoFe2O4 NPs acted as an excellent green heterogeneous nanocatalyst for synthesis of β-enaminones and gave good recyclability, while showing insignificant loss of their activity. Graphical Abstract: [Figure not available: see fulltext.].

Cu catalyzed cross-dehydrogenative coupling reaction for the synthesis of 3-hydroxy-2-pyrrolidinones

A new convenient strategy for the synthesis of 3-hydroxy-2-pyrrolidinone derivatives featuring regioselective C–C coupling has been developed. This is a Cu (II) catalyzed cross dehydrogenative coupling (CDC) involving enamino-ketones of benzyl amines and di-alkyl acetylenedicarboxylate, followed by cyclization by primary amines. TBHP (tert-butyl hydroperoxide) has been used as the oxidant to promote the coupling protocol. This synthetic route principally demonstrates the scope of CDC reaction and also applicable to gram-scale synthesis.

FeCl3-Catalyzed Combinatorial Synthesis of Functionalized Spiro[Indolo-3,10′-indeno [1,2- b ]quinolin]-trione Derivatives

An efficient, inexpensive, environmentally friendly and high yield one-pot route to new spiro[indolo-3,10′-indeno [1,2-b]quinolin]-trione derivatives has been developed, involving three-component reaction of enaminones, N-substituted isatins and Indane-1,3-dione catalyzed by FeCl3. The approach to this spiro-heterocycle is noteworthy because it results in the formation of three new σ (two C-C and one C-N) bonds in a single operation, leading to the construction of novel spiro skeleton. This method works on a large scale in excellent yields.

Zeolite (ZSM-5) as a highly efficient and heterogeneous catalyst for the synthesis of β-Enaminones and β-Enamino esters

Several β-enaminones and β-enaminoesters have been synthesized in high yields from amine and β-diketone in the presence of Zeolite (ZSM-5) as a catalyst. This method is applicable to both cyclic and acyclic ketones with aromatic and aliphatic amines. Copyright E-Journal of Chemistry 2004-2011.

A green solventless protocol for the synthesis of β-Enaminones and β -Enamino esters using silica sulfuric acid as a highly efficient, heterogeneous and reusable catalyst

Silica sulfuric acid is utilized as a green, highly efficient, heterogeneous and recyclable catalyst for the preparation of β-enaminones and β -enamino esters from amines and β -dicarbonyl compounds under solvent-free conditions at 80 °C. Using this method, the title compounds are produced in high to excellent yields and in short reaction times.

Silica-supported LiHSO4 as a highly efficient, heterogeneous and reusable catalytic system for the solvent-free synthesis of β-enaminones and β-enamino esters

A highly efficient, simple and green procedure for the synthesis of β-enaminones and β-enamino esters is described. The reaction of aromatic and aliphatic amines with β-dicarbonyl compounds using catalytic amount of silica-supported LiHSO4 (LiHSO4/SiO2) under solvent-free conditions at 80 °C affords the title compounds in high to excellent yields and in short reaction times.