333401-67-5

Upstream product

• 222022-92-6 (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol 
• 222022-93-7 (1'S)-1,2-dimethoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene 
• 222022-91-5 (1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde 
• 223751-48-2 (1'S)-1-bromo-2,3-dimethoxy-6-methyl-4-(1',2',2'-trimethylcyclopentyl)benzene 

Downstream Products

• 118584-11-5 (-)-mastigophorene C 
• 333401-69-7 (1''S,1'''S)-4,5'-bis(1,2,2-trimethylcyclopentyl)-6-methyl-2,3,3',4'-tetramethoxy-diphenylmethane 

Relevant academic research and scientific papers

First total synthesis of the mastigophorenes C and D and of simplified unnatural analogs

The first total synthesis of the mastigophorenes C (2) and D (3), natural 'dimeric' sesquiterpenes isolated from the liverwort Mastigophora diclados with interesting biological activities, is described. As previously for mastigophorenes A (1) and B, the divergent synthetic approach was first optimized on a simplified model system with a tert-butyl group instead of the chiral cyclopentyl residue, also in order to find more easily available compounds with similar or even improved biological activity.