222022-92-6

Basic information

• Product Name: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol
• Synonyms: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol
• CAS NO: 222022-92-6
• Molecular Weight: 278.392
• Mol File: 222022-92-6.mol

Chemical Properties

• CAS DataBase Reference: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol(222022-92-6)
• EPA Substance Registry System: (1'S)-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzyl alcohol(222022-92-6)

Safety Data

• Hazardous Substances Data: 222022-92-6(Hazardous Substances Data)

Upstream product

• 222022-93-7 (1'S)-1,2-dimethoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene 
• 185967-11-7 (1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde 
• 222022-91-5 (1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde 

Downstream Products

• 222022-91-5 (1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde 
• 405063-84-5 3,3'-Dimethoxy-6,6'-dimethyl-4,4'-bis-((S)-1,2,2-trimethyl-cyclopentyl)-biphenyl-2,2'-diol 
• 222022-97-1 1-Benzyloxy-2-isopropoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene 
• 222022-96-0 1-Benzyloxy-2-ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-benzene 
• 222022-89-1 2-Ethoxy-5-methyl-3-((S)-1,2,2-trimethyl-cyclopentyl)-phenol 
• 333401-67-5 [2,3-Dimethoxy-6-methyl-4-((S)-1,2,2-trimethyl-cyclopentyl)-phenyl]-[3,4-dimethoxy-5-((S)-1,2,2-trimethyl-cyclopentyl)-phenyl]-methanol 
• 333401-69-7 (1''S,1'''S)-4,5'-bis(1,2,2-trimethylcyclopentyl)-6-methyl-2,3,3',4'-tetramethoxy-diphenylmethane 
• 333401-68-6 1,2-bis[5'-((1S)-1,2,2-trimethylcyclopentyl)-3',4'-dimethoxyphenyl]ethane 
• 185967-11-7 (1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde 
• 118584-12-6 (-)-mastigophorene D 
• 118584-11-5 (-)-mastigophorene C 
• 304859-84-5 (1''S,1'''S)-[2'-methoxy-5'-methyl-3'-(1''',2''',2'''-trimethylcyclopentyl)-phenyl] 2-bromo-5-(1'',2'',2''-trimethylcyclopentyl)-3,4-(diphenylmethylidenedioxy)benzoate 
• 304859-85-6 (1'S,1''S)-4-methoxy-3,8-di(1,2,2,-trimethylcyclopentyl)-1-methyl-9,10(diphenylmethylidenedioxy)-dibenzo[b,d]pyran-6-one 
• 304859-79-8 (1''S,1'''S)-[2'-methoxy-5'-methyl-3'-(1''',2''',2'''-trimethylcyclopentyl)-phenyl] 2-bromo-3,4-dimethoxy-5-(1'',2'',2''-trimethylcyclopentyl)benzoate 

Relevant articles and documents

First total synthesis of the mastigophorenes C and D and of simplified unnatural analogs

The first total synthesis of the mastigophorenes C (2) and D (3), natural 'dimeric' sesquiterpenes isolated from the liverwort Mastigophora diclados with interesting biological activities, is described. As previously for mastigophorenes A (1) and B, the divergent synthetic approach was first optimized on a simplified model system with a tert-butyl group instead of the chiral cyclopentyl residue, also in order to find more easily available compounds with similar or even improved biological activity.

Nondynamic and dynamic kinetic resolution of lactones with stereogenic centers and axes: Stereoselective total synthesis of herbertenediol and mastigophorenes A and B

The stereoselective total synthesis of the sesquiterpene herbertenediol (3) and of its naturally occurring dimers, mastigophorenes A [(P)-1] and B [(M)-1], is described. Following the 'lactone concept', the configuration at the biaryl axis was atropo-dive

First synthesis of mastigophorenes A and B, by biomimetic oxidative coupling of herbertenediol

The first synthesis of mastigophorenes A and B by oxidative phenolic coupling of partially protected derivatives of their joint natural monomeric half, herbertenediol, is described. The synthesis starts from this diol itself or from the corresponding aldehyde, both available by isolation from the liverwort, Herbertus aduncus. After transformation of herbertenediol to a chemically appropriate monophenolic coupling precursor, the oxidative dehydrodimerization was brought about using (tert-BuO)2, followed by deprotection to give mastigophorenes A and B in their 'natural' atropisomeric ratio, as isolated from the liverwort.