333407-18-4Relevant academic research and scientific papers
Synthesis of novel 3-(quinazol-2-yl)-quinolines via SNAr and aluminum chloride-induced (hetero) arylation reactions and biological evaluation as proteasome inhibitors
Berrée, Fabienne,Boualia, Imen,Boulcina, Raouf,Carboni, Bertrand,Debache, Abdelmadjid,Roisnel, Thierry,Vidal, Jo?lle
, (2020)
A new series of 3-(quinazol-2-yl)-quinolines was synthesized by SNAr reaction from easily prepared 4-chloro-2-(2-chloroquinolin-3-yl)quinazolines and a range of phenols and thiophenol as nucleophiles. The AlCl3-mediated C–C bond formation was also successfully exploited to introduce aryl and hereroaryl substituents on one or both heterocyclic units. These procedures afford efficient syntheses of polysubstituted 3-(quinazol-2-yl)-quinolines in few steps and high yields. Some of these polysubstituted 3-(quinazol-2-yl)-quinolines inhibit the human 20S proteasome.
Sulfonic acid functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones In memory of Dr. K. Anji Reddy, the founder of Dr. Reddy's Laboratories Ltd DRL Communication no.: IPDO IPM-00443
Dhanunjaya Rao,Vykunteswararao,Bhaskarkumar,Jogdand, Nivrutti R.,Kalita, Dipak,Lilakar, Jaydeep Kumar D.,Siddaiah, Vidavalur,Douglas Sanasi, Paul,Raghunadh, Akula
, p. 4714 - 4717 (2015/08/06)
Abstract An efficient and green approach has been developed for the synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones directly from corresponding substituted aromatic and aliphatic aldehyde and anthranilamide using recyclable polymer supported sulfonic acid catalyst under aqueous conditions. Environmental acceptability, operational simplicity, low cost, excellent functional group compatibility, and high yields are the important features of this protocol.
