3335-45-3

Basic information

• Product Name: 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE
• Synonyms: 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE;2-HYDROXY-6-(THIEN-2-YL)-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE;2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile 97%;2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile97%;2-oxo-6-thiophen-2-yl-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile
• CAS NO: 3335-45-3
• Molecular Formula: C₁₁H₅F₃N₂OS
• Molecular Weight: 270.23
• Mol File: 3335-45-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 278°C
• Boiling Point: 390.2°Cat760mmHg
• Flash Point: 189.8°C
• Appearance: /
• Density: 1.52g/cm³
• Sensitive: Stench
• CAS DataBase Reference: 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE(3335-45-3)
• EPA Substance Registry System: 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE(3335-45-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-36-25
• Safety Statements: 26-36/37/39-45
• RIDADR: 3439
• WGK Germany: 3
• Hazardous Substances Data: 3335-45-3(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE is a chemically synthesized compound that belongs to the heterocyclic organic compounds category. 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE, which appears to contain fluorine, nitrogen, nitrogenous bases, especially nicotinonitrile, and sulfur from the thienyl group, has potential applications in various industrial and scientific fields. However, specific details regarding its physical properties, toxicity, and uses are not widely available. It could serve as a precursor for a variety of complex molecules due to its aromatic thiophene ring and trifluoromethyl groups, which are relevant in the field of organic and medicinal chemistry. Detailed research and studies are required to fully understand the potential applications and safety measures associated with this compound.

Upstream product

• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 
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• 88-15-3 2-Acetylthiophene 
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Downstream Products

• 924990-23-8 C₁₃H₇F₃N₂O₃S 
• 1581726-07-9 ethyl 3-amino-6-(thiophen-2-yl)-4-(trifluoromethyl) furo [2,3-b]pyridine-2-carboxylate 

Relevant articles and documents

Synthesis and antimicrobial activity of 4-trifluoromethylpyridine nucleosides

4-Trifluoromethylpyridine derivatives 4-8 represent good candidates for the discovery of new antibacterial agents. Fluorinated pyridine nucleosides 4-7 and non-nucleoside analogues 8a,b were synthesized and evaluated for their antibacterial activities aga

Synthesis of novel hetero ring fused pyridine derivatives; Their anticancer activity, CoMFA and CoMSIA studies

A series of novel furo[2,3-b]pyridine-2-carboxamide 4a–h/pyrido[3′,2′:4,5]furo[3,2-d] pyrimidin-4(3H)-one derivatives 5a–p were prepared from pyridin 2(1H) one 1 via selective O-alkylation with α-bromoethylester followed by cyclization, then reaction with

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.