2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

Base Information

Chemical Name:2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile
CAS No.:3335-45-3
Molecular Formula:C11H5 F3 N2 O S
Molecular Weight:270.23
Hs Code.:2934999090
European Community (EC) Number:809-111-6
DSSTox Substance ID:DTXSID40351341
ChEMBL ID:CHEMBL3627736
Mol file:3335-45-3.mol

Synonyms:3335-45-3;22123-11-1;2-hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile;2-Oxo-6-thiophen-2-yl-4-trifluoromethyl-1,2-dihydropyridine-3-carbonitrile;2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile;2-Hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile;2-oxo-6-thiophen-2-yl-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;CHEMBL3627736;MFCD00741364;2-oxo-6-(2-thienyl)-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile;2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile;3-cyano-6-(2-thienyl)-4-trifluoromethyl-2(1h)-pyridone;Maybridge1_006155;2-HYDROXY-6-THIEN-2-YL-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE;HMS558P17;2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile;DTXSID40351341;CHEBI:194820;UBBGOCKMIMCHLZ-UHFFFAOYSA-N;BDBM50129066;MFCD00052654;STK053367;2-hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile;AKOS000487342;AKOS005083838;2K-305S;SB55372;CS-0320666;FT-0612561;FT-0638191;1T-0036;3-cyano-6-(2-thienyl)-4-trifluoromethyl pyridone;A815946;SR-01000507121;J-014528;SR-01000507121-1;3-cyano-4-trifluoromethyl-6-(2-thienyl)-1h-pyridone;F0903-0102;3-Cyano-4-trifluoromethyl-6-(2-thienyl)-2(1H)-pyridone;2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)-nicotinonitrile;2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile, AldrichCPR;2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile 97%;2-oxo-6-thiophen-2-yl-4-(triluoromethyl)-1H-pyridine-3-carbonitrile;4-(trifluoromethyl)-1,2-dihydro-2-oxo-6-(thiophen-2-yl)pyridine-3-carbonitrile;2-oxo-6-(2-thienyl)-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;2-Oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Suppliers and Price of 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile 97%
10 g
$ 384.00

SynQuest Laboratories
2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile 97%
5 g
$ 218.00

SynQuest Laboratories
2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile 97%
1 g
$ 88.00

Sigma-Aldrich
2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile Aldrich
1g
$ 55.10

Matrix Scientific
2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile
10g
$ 427.00

Matrix Scientific
2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile
1g
$ 91.00

Matrix Scientific
2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile
5g
$ 269.00

Crysdot
2-Hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile 97%
25g
$ 529.00

Apolloscientific
2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile
10g
$ 240.00

Apolloscientific
2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile
5g
$ 136.00

Total 14 raw suppliers

Chemical Property of 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

Chemical Property:

Melting Point:278°C
Boiling Point:390.2°Cat760mmHg
Flash Point:189.8°C
PSA：85.15000
Density:1.52g/cm³
LogP:3.40618
Sensitive.:Stench
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:270.00746845
Heavy Atom Count:18
Complexity:498

Purity/Quality:

99%, ^*data from raw suppliers

2-Hydroxy-6-thien-2-yl-4-(trifluoromethyl)pyridine-3-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,T
Statements: 36/37/38-36-25
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC(=C1)C2=CC(=C(C(=O)N2)C#N)C(F)(F)F

Technology Process of 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

There total 3 articles about 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 107-91-5
cyanoacetic acid amide

: 3335-45-3
2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: With potassium hydroxide; at 25 ℃; regioselective reaction; neat (no solvent, solid phase);
DOI:10.1080/17415993.2011.628994

Reference yield: 62.0%

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 2700-22-3
Benzylidenemalononitrile

: 3335-45-3
2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 81829-55-2
2-(3-(2-thienyl)-3-oxo-1-phenylpropyl)malononitrile

Guidance literature:: With morpholine; In ethanol; for 1.5h; Heating;

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 3335-45-3
2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol; tetrahydrofuran / 0 - 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; sodium methylate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2014.01.075