3336-53-6Relevant academic research and scientific papers
STUDIES ON SRN1 REACTIONS - 9 A NEW ACCESS TO THE ISOQUINOLINE RING SYSTEM
Beugelmans, Rene,Chastanet, Jacqueline,Roussi, Georges
, p. 311 - 314 (2007/10/02)
The SRN1 reaction between o-halogeno-benzylamines and enolates derived from a series of ketones and aldehydes affords 1, 2 dihydro-isoquinolines from which are obtained (i) the isoquinoline derivatives, either spontaneously or by treatment on Pd-C and (ii) the 1, 2, 3, 4 tetrahydro-isoquinoline derivatives after sodium borohydride reduction.
NOUVELLE SYNTHESE DU SQUELETTE DIHYDRO-1,2 ISOQUINOLEINE PAR REACTION DE SUBSTITUTION NUCLEOPHILE RADICALAIRE EN CHAINE (SRN1)
Beugelmans, R.,Chastanet, J.,Roussi, G
, p. 2313 - 2314 (2007/10/02)
The SRN1 reaction between ortho-iodo-benzylamine and ketone enolates affords the 1,2-dihydroisoquinoline ring system from which the 3-substituted isoquinolines or the 1,2,3,4-tetrahydroisoquinoline are obtained.
