33369-26-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 3-(ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetate is used as a building block in organic synthesis for the development of pharmaceuticals. Its versatile chemical properties and reactivity allow for the creation of a wide range of bioactive molecules, contributing to the advancement of new drug formulations and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, ethyl 3-(ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetate serves as a key intermediate in the synthesis of various agrochemicals. Its unique structure enables the production of compounds with specific pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Research Applications:
Ethyl 3-(ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetate is utilized in research settings to explore its chemical properties and potential applications. Its reactivity and structural features make it an interesting subject for studies in organic chemistry, potentially leading to the discovery of new synthetic pathways and applications in various fields.

InChI:InChI=1/C13H19NO4/c1-5-17-11(15)7-10-12(13(16)18-6-2)9(3)8-14(10)4/h8H,5-7H2,1-4H3

Upstream product

• 570-08-1 diethyl acetylmalonate 
• 78-95-5 chloroacetone 
• 74-89-5 methylamine 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 33369-45-8 3-carboxy-1,4-dimethyl-1H-pyrrole-2-acetic acid 
• 82875-55-6 3-(Ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetic Acid 

Downstream Products

• 931-25-9 1,2,4-trimethyl-1H-pyrrole 
• 55770-78-0 ethyl 1,2,4-trimethyl-1H-pyrrole-3-carboxylate 
• 82875-55-6 3-(Ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetic Acid 
• 33369-47-0 ethyl 1,4-dimethyl-1H-pyrrole-2-acetate 
• 33369-46-9 Ethyl 3-Carboxy-1,4-dimethyl-1H-pyrrole-2-acetate 
• 33369-27-6 ethyl 5-(4-chlorobenzoyl)-3-(ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetate 
• 33369-32-3 2-ethoxycarbonylmethyl-1,4-dimethyl-5-(4-methyl-benzoyl)-pyrrole-3-carboxylic acid ethyl ester 
• 33369-45-8 3-carboxy-1,4-dimethyl-1H-pyrrole-2-acetic acid 
• 86814-97-3 1,3-dimethyl-1,7-dihydropyrano<4,3-b>pyrrole-4,6-dione 

Relevant academic research and scientific papers

Catalytic asymmetric tamura cycloadditions

In the presence of a novel, tert-butyl-substituted squaramide-based catalyst, enolizable anhydrides react with alkylidene oxindoles to generate spirooxindole products of significant synthetic interest with excellent enantio- and diastereocontrol. The methodology is of wide scope and encompasses both homophthalic and glutaconic anhydride derivatives, which lead to structurally diverse products. Glutaconic acid-derived anhydrides undergo a clean post-cyclization decarboxylation process which is not a feature of reactions involving homophthalic acid-derived anhydrides. The unusual influence of reaction temperature on diastereocontrol has been probed, with reactions occurring at 30 °C and -30 °C delivering products epimeric at one stereocenter only, in near optical purity. Squared away: The first strategy for bringing about enantioselective Tamura reactions is reported. In the presence of a squaramide-based catalyst, enolizable anhydrides react with alkylidene oxindoles to generate spirooxindole products with excellent enantio- and diastereocontrol. The methodology is of wide scope and leads to structurally diverse products.

1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia

1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.

Esters and amides of substituted pyrrole acetic acids

Esters and amides of substituted pyrrole acetic acids are useful in the treatment of colonic polyps.

Process for producing substituted pyrroles

A process for the preparation of alkyl 1,4-dimethyl-3-ethoxycarbonylpyrrole-2-acetate compounds by reacting a diloweralkyl acetone dicarboxylate, a chloromethyl lower alkyl ketone and an aqueous loweralkylamine in the presence of an added organic brominated or chlorinated hydrocarbon co-solvent.

Process for producing substituted pyrroles

An acid having a dissociation constant of at least 1.3×10-5 at 25° C. is used to enhance the yield of alkyl, 1,4-dialkyl-3-alkoxycarbonylpyrrole-2-acetate in the reaction of a chloromethyl alkyl ketone with a dialkyl acetone dicarboxylate and an alkylamine in a reaction medium comprising an organic solvent. The preferred acid is formic acid.