33373-89-6

Usage

General Description

2-amino-N-1,3-thiazol-2-ylbenzamide, also known as ATB-346, is a novel chemical compound with potential anti-inflammatory and analgesic properties. It is a benzamide derivative with a thiazole ring, and it acts as a non-steroidal anti-inflammatory drug (NSAID) and an inhibitor of the enzyme cyclooxygenase-2 (COX-2). ATB-346 has shown promising results in preclinical studies, demonstrating reduced gastrointestinal toxicity compared to traditional NSAIDs, such as naproxen. It is being developed as a potential treatment for chronic pain and inflammatory conditions, with the aim of providing effective pain relief while minimizing the risk of gastrointestinal damage commonly associated with NSAID use. Further research and clinical trials are needed to fully assess the efficacy and safety of ATB-346 for therapeutic use.

InChI:InChI=1/C10H9N3OS/c11-8-4-2-1-3-7(8)9(14)13-10-12-5-6-15-10/h1-6H,11H2,(H,12,13,14)

Upstream product

• 118-92-3 anthranilic acid 
• 96-50-4 2-thiazolylamine 
• 21563-73-5 2-aminobenzoyl chloride 
• 118-48-9 isatoic anhydride 

Downstream Products

• 33441-00-8 (2-thiazol-2-ylcarbamoyl-phenyl)-carbamic acid ethyl ester 

Relevant academic research and scientific papers

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

NaNO2/I2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization.