333736-15-5Relevant academic research and scientific papers
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor
Hodous, Brian L.,Geuns-Meyer, Stephanie D.,Hughes, Paul E.,Albrecht, Brian K.,Bellon, Steve,Bready, James,Caenepeel, Sean,Cee, Victor J.,Chaffee, Stuart C.,Coxon, Angela,Emery, Maurice,Fretland, Jenne,Gallant, Paul,Gu, Yan,Hoffman, Doug,Johnson, Rebecca E.,Kendall, Richard,Kim, Joseph L.,Long, Alexander M.,Morrison, Michael,Olivieri, Philip R.,Patel, Vinod F.,Polverino, Anthony,Rose, Paul,Tempest, Paul,Wang, Ling,Whittington, Douglas A.,Zhao, Huilin
, p. 611 - 626 (2007/10/03)
Inhibition of angiogenesis is a promising and clinically validated approach for limiting tumor growth and survival. The receptor tyrosine kinase Tie-2 is expressed almost exclusively in the vascular endothelium and is required for developmental angiogenes
Kinase inhibitors
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Page/Page column 227, (2010/02/07)
The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.
Substituted triazinyl amide derivatives and methods of use
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, (2008/06/13)
The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.
