333753-72-3

Usage

Uses

Used in Pharmaceutical Industry:
Desacetyl-N,O-descarbonyl Linezolid is used as an impurity in the development and production of Linezolid, an oxazolidinone antimicrobial. Its presence is crucial for understanding the overall efficacy and safety profile of Linezolid, as it may contribute to potential side effects or interactions with other compounds. By studying and controlling the levels of this impurity, researchers can optimize the therapeutic benefits and minimize adverse effects of Linezolid in treating bacterial infections.

Upstream product

• 1260086-02-9 (dl)-N-(3-chloro-2-hydroxypropyl)-3-fluoro-4-morpholinoaniline 
• 874340-08-6 N-[3-phthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(4-morpholinyl)aniline 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 868405-66-7 N-[3-chloro-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholin-4-yl)aniline 

Relevant academic research and scientific papers

Linezolid related substance, and preparation method and application thereof

The invention belongs to the technical field of medicine synthesis, and discloses a linezolid related substance, and a preparation method and application thereof. The related substance is a compound Iwith a chemical formula of C17H24FN3O4, and the prepara

A oxazolidinone compounds of preparation method

The invention discloses a method for preparing an oxazolidinone compound. The method comprises the following steps of carrying out ammonolysis reaction on a racemic or optically active 3-chloro-2-hydroxypropyl aniline compound (2) as a starting material and ammonia in a proper solvent and under alkaline condition to obtain a 3-amino-2-hydroxypropyl aniline compound (3); carrying out acylation reaction on the compound (3) to obtain 3-acylamino-2-hydroxypropyl aniline compound (4); and carrying out cyclization reaction on the compound (4) and a corresponding acylating reagent to obtain the racemic or optically active oxazolidinone compound (II) as shown in the description, wherein R1 represents morpholinyl or 3-oxo-4-morpholinyl; R2 represents H or F; and R3 represents C1-12 alkyl, 5-chloro-thiophen-2-yl, thiophen-2-yl or 4,5-dichloro-2-yl; and the compound is a racemate and (S)- or (R)- optical isomers.

Preparing method for linezolid and intermediate thereof

The invention relates to a preparing method for linezolid and an intermediate thereof. The preparing method includes the step that 4-chloracetyl acetate compound (I) serves as a starting raw material and is subjected to asymmetric chiral reduction, acetylation, condensation, ammonolysis, Hoffman degradation, acetylation and cyclization to obtain (S)-N-[[3-[3-fluoro-4-(4-morpholinyl) phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide (linezolid). Compared with other linezolid synthesis methods, the preparing method is high in total yield and product purity, raw materials are cheap and easy to obtain, flammable, combustible and poisonous reagents are avoided, and the production technology is safe and environmentally friendly.