3338-22-5

Usage

Uses

Used in Pharmaceutical Synthesis:
N-propan-2-ylglycine is used as a building block in the synthesis of pharmaceuticals for its ability to modulate the properties of peptide and protein structures. Its incorporation can lead to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, N-propan-2-ylglycine is used as a key component in the production of various agrochemicals, contributing to the development of more effective and environmentally friendly products.
Used in Chiral Catalysts:
N-propan-2-ylglycine is utilized as a chiral catalyst in asymmetric synthesis, enabling the production of enantiomerically pure compounds, which are essential in the pharmaceutical and chemical industries.
Used as a Precursor in Organic Compounds Production:
N-propan-2-ylglycine serves as a precursor in the synthesis of a wide range of organic compounds, further expanding its applications in the chemical industry.
Used in Medicinal Chemistry and Drug Discovery:
Due to its potential biological activities and ability to modulate the properties of peptide and protein structures, N-propan-2-ylglycine is used in medicinal chemistry and drug discovery for the development of novel therapeutic agents.

Upstream product

• 90544-82-4 (Formyl-isopropyl-amino)-acetic acid 
• 103218-05-9 (Isopropylimino)malonsaeure-diethylester 

Downstream Products

• 158831-35-7 N-carboxybenzyl-N-isopropylaminoacetic acid 
• 3183-21-9 2-(2-propylamino)acetic acid 

Relevant academic research and scientific papers

Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents

Novel compounds of the formula I are described: wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms, R2=H, CH3 or CH2CH3 R3=H or CH3 R4=H or CH3 R5=lower alkyl having from 1 to 5 carbon atoms n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C≡N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.

Rearrangement of Azidomalonic Esters

Dimethyl azidomalonate (4) is photolyzed under loss of nitrogen and rearrangement of one methoxycarbonyl group to form the mixture of Z and E isomers of the α,β-unsaturated amino acid esters 8 and 9.On photolysis of isopropyl- and isobutylazidomalonates 10 migration of the alkyl group is observed exclusively.The (alkylimino)malonates 14 so formed have been hydrogenated and hydrolyzed to give the N-alkylglycine derivatives 16.

Synthesis of Strombine. A New Method for Monocarboxymethylation of Primary Amines

Many common methods for monocarboxymethylation of primary amines give various amounts of dialkylated by-products.In this work the reaction of two equivalents of glyoxilic acid with representative primary aliphatic and aromatic amines, as well as with amino acids and a dipeptide, is shown to give only the N-(carboxymethyl)-N-formyl derivative of the amine under mild conditions in carboxylic acid solvents.Hydrolysis then produces the monocarboxymethylated primary amine in good to exellent overall yield.Proof that the intermediate product is not obtained via the Leuckart reaction is given.