3183-21-9

Usage

Uses

Used in Pharmaceutical Industry:
(ISOPROPYLAMINO)ACETIC ACID is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its role in drug development is crucial due to its ability to be incorporated into the molecular structures of medications, potentially enhancing their efficacy and properties.
Used in Agrochemical Industry:
In the agrochemical sector, (ISOPROPYLAMINO)ACETIC ACID is utilized as an intermediate in the production of agrochemicals. Its involvement in this industry is significant for the development of compounds that can improve crop protection and yield.
Used in Organic Synthesis:
(ISOPROPYLAMINO)ACETIC ACID is used as a building block in organic synthesis for creating a wide range of organic compounds. Its structural properties make it a valuable component in the synthesis of various organic molecules for different applications.
Used in Analytical and Clinical Chemistry:
(ISOPROPYLAMINO)ACETIC ACID is used as a chelating agent in the preparation of metal chelates. This application is important for various analytical techniques and clinical chemistry processes, where metal chelates can be used for detection, quantification, and other purposes.
Further research is necessary to explore and evaluate the potential applications of (ISOPROPYLAMINO)ACETIC ACID in additional fields, expanding its utility and impact in scientific and industrial applications.

InChI:InChI=1/C5H11NO2/c1-4(2)6-3-5(7)8/h4,6H,3H2,1-2H3,(H,7,8)

Upstream product

• 691001-13-5 N-isopropylidene-glycine 
• 105-36-2 ethyl bromoacetate 
• 75-31-0 isopropylamine 
• 3338-22-5 N-isopropylglycine hydrochloride 
• 3183-22-0 ethyl 2-(isopropylamino)acetate 
• 1018513-19-3 N-(1-cyano-1-methyl-ethyl)-glycine ethyl ester 
• 131543-46-9 Glyoxal 
• 298-12-4 Glyoxilic acid 
• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 
• 107-16-4 glycolonitrile 
• 103218-05-9 (Isopropylimino)malonsaeure-diethylester 
• 64-17-5 ethanol 

Downstream Products

• 6939-16-8 N-Nitroso-N-isopropyl-glycin 
• 154509-63-4 2-(tert-butoxycarbonyl(isopropyl)amino)acetic acid 
• 6939-17-9 N-isopropylsydnone 
• 305790-83-4 [(5-Bromo-2-nitro-phenyl)-isopropyl-amino]-acetic acid 
• 1310682-48-4 N-(tert-butoxycarbonyl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-50-8 N-(ethoxycarbonyl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-51-9 N-(3,4-dichlorophenyl)-N'-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-N''-(trimethylacetyl)guanidine 
• 1310682-52-0 N-(2-ethylbutyryl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-53-1 N-(3,4-dichlorophenyl)-N'-isopropyl-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-54-2 N-(tert-butyl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-55-3 N-(ethyl)-N'-(3,4-dichlorophenyl)-N''-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-56-4 N-(adamantyl)-N'-(3,4-dichlorophenyl)-N-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)guanidine 
• 1310682-68-8 2,2-dimethylpropionic acid 2-[N'-(3,4-dichlorophenyl)-N''-(2,2-dimethylpropionyl)guanidino]-1-isopropyl-1H-imidazol-4-yl ester 
• 1310682-63-3 N-(3,4-dichlorophenyl)-N'-(1-isopropyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)pyrrolidine-1-carboxamidine 

Relevant academic research and scientific papers

Highly active bidentate N-heterocyclic carbene/ruthenium complexes performing dehydrogenative coupling of alcohols and hydroxides in open air

Eight bidentate NHC/Ru complexes, namely [Ru]-1-[Ru]-8, were designed and prepared. In particular, [Ru]-2 displayed extraordinary performance even in open air for the dehydrogenative coupling of alcohols and hydroxides. Notably, an unprecedentedly low catalyst loading of 250 ppm and the highest TON of 32 800 and TOF of 3200 until now were obtained.

General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2

An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.

Thermoresponsive poly(N -C3 glycine)s

Ring-opening polymerization of N-substituted glycine N-carboxyanhydrides (NCAs) was applied to prepare a series of well-defined poly(N-C3 glycine)s (C3 = n-propyl, allyl, propargyl, and isopropyl), polypeptoids, with molecular weights in the range of 1.8-6.6 kg mol-1. Poly(N-isopropyl glycine), a previously unreported polypeptoid, could be obtained by bulk polymerization of the corresponding NCA in the melt. The samples were characterized by spectroscopy (NMR and FT-IR), size exclusion chromatography (SEC), and matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-ToF MS). The polymers could be dispersed in water up to 20-40 g L -1; the poly(N-propargyl glycine) was not soluble in water. Turbidity measurements of the three water-soluble polypeptoids illustrated cloud point temperatures dependent on structural and electronic properties of the side chain. The cloud point temperatures were found to increase in the order C3 = n-propyl (15-25 C) allyl (27-54 C) isopropyl (47-58 C). Long-term annealing of the aqueous solution of poly(N-{n-propyl} glycine) and poly(N-allyl glycine) above the cloud point temperature resulted in the formation of crystalline microparticles with melting points of 188-198 and 157-165 C (differential scanning calorimetry, DSC), respectively, and rose bud type morphology (scanning electron microscopy, SEM).

2-GUANIDINO-4-OXO-IMIDAZOLINE DERIVATIVES AS ANTIMALARIAL AGENTS, SYNTHESIS AND METHODS OF USE THEREOF

The present invention relates to new 2-guanidino-4-oxo-imidazoline derivatives (deoxo-IZ), methods of making these compounds, compositions containing the same, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives

A series of 2-guanidino-4-oxoimidazoline (deoxo-IZ) derivatives was prepared and showed potent antimalarial activities in rodent and Rhesus models. Compound 8e, the most potent analogues of this series, is the first non-8-aminoqinoline antimalarial that demonstrated radical curative activity in non-human primate by oral route and showed causal prophylactic activity comparable to that of the commonly used clinical drugs in Rhesus monkeys infected with sporozoites of Plasmodium cynomolgi. The metabolic stability and metabolites profile indicated that the new deoxo-IZ derivatives (8) may act as prodrugs of the corresponding IZ (1 and 2) derivatives.

Mesoionic compounds. 10. Preferred conformation of a 3-alkyl and 3-aryl-substituent in 4-unsubstituted and 4-acylated monocyclic munchnones and sydnones

A new 4-unsubstituted monocyclic oxazolium-5-olate (7c) was generated and NMR-characterized. Several 3-alkyl- and 3-aryl-4-acylated monocyclic munchnone and sydnone derivatives were also prepared. From NMR experimental data and theoretical calculations di

Preparation of N-Boc N-alkyl glycines for peptoid synthesis

A series of N-tert-butoxycarbonylated N-allyl, N-propargyl, N-benzyl or branched N-alkyl glycines, useful building blocks for the synthesis of N-alkyl glycine oligomers, have been prepared by N-alkylation of N-Boc glycine or by a two-step method: reductive alkylation and tert-butoxycarbonylation.

Preparation of N-substituted amino acids

An N-substituted amino acids can be prepared by the steps of: bringing together under reaction condition glyoxal and a source of sulfur dioxide in an aqueous medium to produce a sulfonated intermediate; and introducing into said medium a nitrogen compound selected from the group consisting of ammonia, a primary amine, and a secondary amine, into said medium containing said intermediate to produce said N-substituted amino acid.

Rearrangement of Azidomalonic Esters

Dimethyl azidomalonate (4) is photolyzed under loss of nitrogen and rearrangement of one methoxycarbonyl group to form the mixture of Z and E isomers of the α,β-unsaturated amino acid esters 8 and 9.On photolysis of isopropyl- and isobutylazidomalonates 10 migration of the alkyl group is observed exclusively.The (alkylimino)malonates 14 so formed have been hydrogenated and hydrolyzed to give the N-alkylglycine derivatives 16.