333959-07-2

Upstream product

• 221178-83-2 6-amino-1,2-dihydro-4-(4-hydroxyphenyl)-2-thioxopyridine-3,5-dicarbonitrile 
• 79-07-2 Chloroacetamide 
• 3785-90-8 2-(4-hydroxyphenylmethylene)malononitrile 
• 133149-51-6 2-cyano-2-(4-hydroxybenzylidene)thioacetamide 
• 221178-81-0 2,6-diamino-4-(4-hydroxyphenyl)-4H-thiopyran-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof

This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, p

USE OF SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES FOR THE TREATMENT OF REPERFUSION INJURY AND REPERFUSION DAMAGE

The invention relates to substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines of formula (I) and their use in medicaments for the prophylaxis and/or treatment of reperfusion injury and damage.

Versatile starting materials for novel 1,ω-bis(pyridin-4-ylphenoxy)alkanes, and their corresponding bis(thieno[2,3-b]pyridin-4-ylphenoxy) derivatives

A synthesis is described, starting from p-hydroxybenzaldehyde, of some new bis(activated styrene) derivatives, and their conversion into novel bis(pyridin-4-yl) ethers and bis(thieno[2,3-b]pyridine) derivatives.

Synthesis and Recyclization of 4-Aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans

Reaction of arylmethylenemalononitriles with cyanothioacetamide or of arylmethylenecyanothioacetamides with malononitrile affords 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans which were further recyclized into 6-amino-4-aryl-3,5-dicyanopyridine-2(1H)-thiones. On the basis of the latter compounds were synthesized substituted 2-alkylthiopyridines and thieno[2,3-b]pyridines. 4-Hydroxybenzalcyanothioacetamide reacts with α-bromoketones by Hantzsch with the formation of thiazolylsubstituted acrylonitriles acylated with acetic anhydride at the OH group.