33398-38-8

Upstream product

• 51318-62-8 ethyl 4-bromo-3-methylcrotonate 
• 603-35-0 triphenylphosphine 
• 65527-85-7 ethyl (E)-4-hydroxy-3-methyl-2-butenoate 
• 62054-49-3 ethyl (E)-3-formyl-2-butenoate 

Downstream Products

• 54200-90-7 5-(2,3,4-trimethylphenyl)-3-methyl-2,4-pentadienol 
• 54200-91-8 3-methyl-5-(2,3,4-trimethylphenyl)penta-2,4-dien-1-yltriphenylphosphonium bromide 
• 54244-21-2 12'-apo-χ-caroten-12'-al 
• 67192-52-3 (2Z)-C₁₅-retinoid 
• 115376-74-4 5-(2,3,4-trimethylphenyl)-3-methyl-2,4-pentadienoic acid 

Relevant academic research and scientific papers

Multifunctional Cyclopentadienes as a Scaffold for Combinatorial Bioorganometallics in [(η5-C5H2R1R2R3)M(CO)3] (M=Re, 99mTc) Piano-Stool Complexes

Multifunctional cyclopentadiene (Cp) ligands and their rhenium and 99mTc complexes were prepared by a versatile synthetic route. The properties of these Cp ligands can be tuned on demand, either during their synthesis (variation of R1) or through post-synthetic functionalization with two equal or different vectors (V1 and V2). Variation of these groups enables a combinatorial approach in the synthesis of bioorganometallic complexes. This is demonstrated by the preparation of Cp ligands containing both electron-donating and electron-withdrawing groups at the R1 position and their subsequent homo- or heterofunctionalization with biovector models (benzylamine and phenylalanine) under standard amide bond-formation conditions. All ligands can be coordinated to the fac-[Re(CO)3]+ and fac-[99mTc(CO)3]+ cores to give tetrafunctional complexes in straightforward and functional-group-tolerant procedures. The 99mTc complexes were prepared in one step, in 30 min, and under aqueous conditions from generator-eluted [99mTcO4]?.

SYNTHETIC INVESTIGATIONS INTO THE CHEMISTRY OF POLYENE COMPOUNDS XLVII. TOTAL SYNTHESIS OF (+/-)-(2E,4E,6E,6Z,8E)-3,7-DIMETHYL-9-(2,6-DIMETHYL-3-OXO-6-ETHOXYCARBONYL-1-CYCLOHEXENYL)-2,4,6,8-NONATETRAENOIC ACID. THE WITTIG REACTION AT HIGH PRESURES

The synthesis of the C20 retinoids (+/-)-2E,4E,6E,6Z,8E-3,7-dimethyl-9-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6,8-nonatetraenoic acid the previously undescribed ethyl (+/-)-2E,4Z,6E-2-isopropenyl-5-methyl-7-(2,6-dimethyl-3-oxo-6-ethoxycarbonyl-1-cyclohexenyl)-2,4,6-heptatrienoate was realized by the C10 + C10 to C20 scheme with the use of the Wittig reaction at high presure.