38256-56-3

Basic information

• Product Name: 1-(2-BROMOETHYL)-2-(BROMOMETHYL)BENZENE
• Synonyms: 1-(2-BROMOETHYL)-2-(BROMOMETHYL)BENZENE
• CAS NO: 38256-56-3
• Molecular Formula: C₉H₁₀Br₂
• Molecular Weight: 277.98
• Mol File: 38256-56-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 283.3 °C at 760 mmHg
• Flash Point: 142 °C
• Appearance: /
• Density: 1.685 g/cm³
• CAS DataBase Reference: 1-(2-BROMOETHYL)-2-(BROMOMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOETHYL)-2-(BROMOMETHYL)BENZENE(38256-56-3)
• EPA Substance Registry System: 1-(2-BROMOETHYL)-2-(BROMOMETHYL)BENZENE(38256-56-3)

Safety Data

• Hazardous Substances Data: 38256-56-3(Hazardous Substances Data)

Usage

General Description

1-(2-Bromoethyl)-2-(bromomethyl)benzene is a chemical compound with the molecular formula C9H10Br2. It is a derivative of benzene with two bromine atoms attached to the carbon atoms, and has a molecular weight of 261.987 g/mol. 1-(2-Bromoethyl)-2-(bromomethyl)benzene is commonly used in organic synthesis and as a building block in the production of various pharmaceuticals and agrochemicals. It is also known for its reactivity and potential as a reagent in chemical reactions, making it a valuable compound in the field of organic chemistry. Additionally, it is important to handle this compound with care due to its potential hazards and toxicity.

Upstream product

• 493-05-0 isochromane 
• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 122444-35-3 2-(2-bromomethyl)-phenethyl alcohol 
• 89-51-0 Homophthalic acid 

Downstream Products

• 7252-02-0 2-((4-aminophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 3340-79-2 2-(o-methylphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 151331-92-9 2-amino-6-chloro-9-<2-(2-bromoethyl)benzyl>purine 
• 38313-67-6 C₁₅H₁₄BrClO 
• 19418-95-2 2-(2-ethylphenyl)acetic acid 
• 109445-99-0 3,4-dihydro-1H-spiro[isoquinoline-2,1'-piperidinium]; bromide 
• 55879-25-9 2-(piperidin-1-ylmethyl)styrene 
• 73357-78-5 vinylbenzyl bromide 
• 55879-27-1 4-(2-ethenylbenzyl)morpholine 

Relevant articles and documents

Synthesis of (+)-(R)-methyl 2-aminotetraline-2-carboxylate: The hydroxypinanone method versus the bislactim method

The methyl ester of 2-aminotetraline-2-carboxylic acid (Atc-OMe), an important residue for modified peptides, could only be synthesized from the Schoellkopf bislactim method, the hydroxypinanone method leading, during the second step, to elimination inste

Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3–sp2 and sp2–sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds

A valuable umpolung strategy that highlights the ambiphilic nature of the bis(phenylsulfonyl)methyl synthon and demonstrates its utility as a synthetic linchpin is reported. Although the bis(phenylsulfonyl)methyl group is typically introduced as an sp3-carbon nucleophile, it is demonstrated that it can also function as an effective sp2-carbon electrophile in the presence of organolithium nucleophiles. Alkyl- and aryllithiums couple with the central carbon of the bis(phenylsulfonyl)methyl unit to ultimately generate trisubstituted alkenes, comprising formal sp3–sp2 and sp2–sp2 cross-couplings between organolithium reagents and bis(sulfones). This process occurs almost instantaneously at ?78 °C in the absence of any transition metals. By developing this curious transformation, it has been demonstrated that bis(phenylsulfonyl)methane is a valuable synthetic linchpin, which can undergo two C?C bond-forming processes as an sp3-nucleophile, followed by a third C?C bond-forming reaction as an effective sp2-electrophile. This discovery significantly enhances the utility of this ubiquitous, but underutilized, linker group.

A new synthesis of indoles via intramolecular cyclization of ?-alkynyl N,N-dialkylanilines promoted by KOt-Bu/DMSO

2-Aryl indoles could be prepared in excellent yields via the intramolecular cyclization of ?-alkynyl N,N-dialkylanilines. The reaction is efficiently promoted by the catalytic amount of KOt-Bu in DMSO at room temperature. A reaction mechanism involving α-