33405-06-0

Usage

General Description

2-[(thien-2-ylcarbonyl)amino]benzoic acid is a chemical compound with the molecular formula C14H11NO3S. It consists of a benzoic acid molecule with a thien-2-ylcarbonyl group and an amino group attached to it. 2-[(THIEN-2-YLCARBONYL)AMINO]BENZOIC ACID has potential applications in the field of pharmaceuticals and organic synthesis due to its unique structure and properties. It can be used as a building block in the synthesis of various organic molecules and as a potential drug candidate for various therapeutic purposes. Additionally, its thien-2-ylcarbonyl group adds to its structural diversity and potential reactivity in chemical reactions. Overall, 2-[(thien-2-ylcarbonyl)amino]benzoic acid is a versatile compound with diverse potential applications in the field of chemistry and pharmaceuticals.

Upstream product

• 26060-06-0 2-Thiophen-2-yl-4H-3,1-benzoxazin-4-one 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 118-92-3 anthranilic acid 
• 55968-16-6 2-(2-thienyl)indole 
• 351184-25-3 2-(2-thienyl)-4H-3,1-benzothiazin-4-one 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 351184-28-6 N-(2-carboxyphenyl)thiophene-2-thiocarboxamide 

Downstream Products

• 26060-06-0 2-Thiophen-2-yl-4H-3,1-benzoxazin-4-one 
• 59455-95-7 4-chloro-2-(thien-2-yl)quinazoline 

Relevant academic research and scientific papers

Benzoic acid derivative as well as preparation method and medicinal application thereof

The invention discloses a benzoic acid derivative as well as a preparation method and a pharmaceutical application thereof, and belongs to the technical field of medicines. The invention specifically discloses a benzoic acid derivative represented by a co

A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2-arylindoles and their antimicrobial activity

A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through the tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in a one-pot fashion under metal-free aerobic conditions. The developed synthetic protocol is operationally simple, tolerates a wide range of functional groups, and is amenable to the gram-scale. Radical trapping experiments revealed that the reaction involves a radical pathway. The synthesized compounds (2a-s) were tested for in vitro antimicrobial activity. Among all screened compounds, 2d showed the maximum antibacterial activity against P. aerugunosa (ZOI = 17 mm, MIC = 32 μg mL-1) and compounds 2d and 2p showed the maximum (32 μg mL-1) antifungal activity against A. flavus and C. albicans.

The design and synthesis of novel orally active inhibitors of AP-1 and NF-κB mediated transcriptional activation. SAR of in vitro and in vivo studies

We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-κB mediated transcriptional activation. Among the derivatives prepared, 1-[2-(2-thienyl)quinazolin-4-ylamino]-3-methyl-3- pyrroline-2,5-dione (10) showed significant activity in an adjuvant-induced arthritis rat model by reducing the swelling by 65% in the non-injected foot. The synthesis, structure-activity relationship, and in vivo activity are described.

Synthesis of derivatives of thiophene using methyl 2-isothiocyanatobenzoate

A variety of 2-substituted thiophenes is readily obtained from 2-(2-thienyl)-4H-3,1-benzothiazin-4-one (2), which is formed when thiophene reacts with methyl 2-isothiocyanatobenzoate (1) in the presence of anhydrous stannic chloride.