33417-05-9

Upstream product

• 134-32-7 1-amino-naphthalene 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 86-57-7 1-Nitronaphthalene 
• 186581-53-3 diazomethane 

Downstream Products

• 124393-69-7 [(4-Methoxy-phenyl)-(naphthalen-1-ylamino)-methyl]-phosphonic acid bis-(2-chloro-ethyl) ester 
• 117358-64-2 10,10-dimethyl-7-(4-methoxylphenyl)-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one 
• 1429117-84-9 6-(4-methoxyphenyl)-11H-benzo[h]indolo[3,2-c]quinoline 
• 1314493-43-0 trans-2-[2-(4-methoxyphenyl)vinyl]-3-(1-naphthyl)-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones

A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4-ones (T

Analgesic, anti-inflammatory activity and docking study of 2-(substituted phenyl)-3-(naphthalen- 1-yl)thiazolidin-4-ones

A potential analgesic and anti-inflammatory activities have been reported in 4-thiazolidinone analogs as well as some drugs bearing naphthyl moiety such as naproxen. Thus a reported series of 2-(substituted phenyl)-3-(naphthalen-1-yl)thiazolidin-4- ones (

Synthesis and Characterization of RhIII-MII(M = Pt, Pd) Heterobimetallic Complexes Based on a Bisphosphine Ligand: Tandem Reactions Using Ethanol

1,1-Bis(diphenylphosphino)methane (dppm) was used as a linker ligand for the preparation of a series of heterobimetallic RhIII-PtII and RhIII-PdII complexes. These complexes were characterized by means of several analytical and spectroscopic methods. The catalytic activities of these heterobimetallic complexes were carried out in three different tandem reactions: Namely, transfer hydrogenation (TH)/dehalogenation (DH), TH/Suzuki-Miyaura coupling, and coupling of benzylic alcohols with nitrobenzenes for Schiff base construction. Ethanol was used as both the solvent and an inexpensive TH reagent, where a broad substrate scope was demonstrated for these tandem reactions. All reactions proceeded smoothly in air at 80-90 °C. The RhIII-PdII complex showed superior catalytic performance in comparison to the RhIII-PtII complexes, its monometallic counterparts, and mixtures of monometallic (RhIII + PdII) complexes. The result demonstrates a cooperative effect between the Rh and Pd metal centers. A mechanism for the catalytic tandem reactions was investigated. It was found that alcohol medium and base are essential.

Direct synthesis of imines by 9-azabicyclo-[3,3,1]nonan-N-oxyl/KOH-catalyzed aerobic oxidative coupling of alcohols and amines

A simple and efficient method for preparation of imines by the oxidative coupling of benzyl alcohols with aromatic amines or aliphatic amines was developed. The reaction was catalyzed by 9-azabicyclo[3.3.1]nonan-N-oxyl (ABNO)/KOH with air as the economic and green oxidant. Under the optimal reaction conditions, a variety of imines were obtained in 80%-96% isolated yields.

Stereoselective Synthesis of 3-(5-Benzoyl-1-methyl-1 H -pyrrol-2-yl)-2-azetidinone Derivatives via an in Situ Generated Ketene

A short route toward β-lactams from tolmetin has been developed. In the key step, a ketene was generated on the C-2 of pyrrole ring and reacted with aromatic imines to form trans -β-lactams as the only observed products. The identification of the ketene was confirmed by reaction with the stable free radical TEMPO (TO·).

Synthesis and antimicrobial evaluation of some 4-thiazolidinone derivatives containing polynuclear hydrocarbon

Some 4-thiazolidinone derivatives have also been known to be associated with several biological activities thus can be utilized as promising scaffold for developing analogues. Aryl aldehydes were treated with naphthylamine to yield corresponding Schiff's

Highly Stereoselective Synthesis of Saccharin-Substituted β-Lactams via in Situ Generation of a Heterosubstituted Ketene and a Zwitterionic Intermediate as Potential Antibacterial Agents

Highly stereoselective synthesis of saccharin derivatives containing functionalized 2-azetidinone moiety was achieved starting from saccharin as an available precursor. The approach to these valuable heterocyclic scaffolds involves a formal [2π + 2π] cycloaddition between Schiff bases and the saccharinylketene as a novel ketene which was generated in situ and an electrocyclic reaction of a zwitterionic intermediate. The identification of the ketene was confirmed by reaction with the stable free radical TEMPO (TO?). Also, the antimicrobial activities of some new substituted saccharin against nine standard bacteria, four bacteria which were isolated from clinical samples and one yeast, were evaluated.

An efficient method for the synthesis of indolo[3,2-c]quinoline derivatives catalyzed by iodine

The reaction of Schiff base and indole catalyzed by iodine in DMA, subsequently treated with DDQ, gave indolo[3,2-c]quinoline derivatives in good yields. The structure of 3e was confirmed by X-ray diffraction analysis. The reaction of Schiff base and indo

Synthesis and photophysical properties of 2-Styrylquinazolin-4-ones

Trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difl uoro derivatives were synthesized by condensation of appropriate 2-methylquinazolin-4-ones with aromatic aldehydes or by the transformation of the heterocycle of 2-methyl-3,1-benzoxazin-4-one under the action of benzylidenephenylamines. Pleiades Publishing, Ltd., 2011.

A thermal study of some Schiff bases derivative of α-napthylamine

Thermal analyses of some Schiff bases, derivative of α-napthylamine, were performed by the DSC, TG and DTA techniques. The thermograms were used to determine various kinetic parameters, such as the order of degradation (n), energy of activation (E), frequ