33419-89-5

Usage

Uses

Used in Pharmaceutical Development:
(5E,9E)-7,8,15,16,17,18-hexahydrodibenzo[e,m][1,4,8,11]tetraazacyclotetradecine is used as a key component in the development of pharmaceutical drugs due to its complex structure and potential biological activity. Its application in this field is aimed at creating novel therapeutic agents that can address various medical conditions.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, (5E,9E)-7,8,15,16,17,18-hexahydrodibenzo[e,m][1,4,8,11]tetraazacyclotetradecine serves as a valuable compound for research purposes. It is employed in the investigation of new drug candidates, potentially leading to the discovery of innovative treatments for a range of diseases and conditions.
Used in Drug Design and Optimization:
(5E,9E)-7,8,15,16,17,18-hexahydrodibenzo[e,m][1,4,8,11]tetraazacyclotetradecine is also utilized in the process of drug design and optimization, where its unique structure can be manipulated to enhance the efficacy and safety of potential pharmaceutical agents. This application aims to improve the overall performance of drugs in clinical settings.
Used in Drug Delivery Systems:
Similar to other complex organic molecules, (5E,9E)-7,8,15,16,17,18-hexahydrodibenzo[e,m][1,4,8,11]tetraazacyclotetradecine may be employed in the development of advanced drug delivery systems. These systems aim to improve the bioavailability, targeting, and overall therapeutic outcomes of drugs by employing innovative carriers and delivery mechanisms.

Upstream product

• 33419-93-1 2,2′-(ethane-1,2-diildiamine)bisbenzaldehyde 
• 107-15-3 ethylenediamine 

Downstream Products

• 88589-00-8 3,4:9,10-dibenzo-1,5,8,12-tetraazacyclotetradecane 

Relevant academic research and scientific papers

Preparation and Spectral Properties of Oxovanadium(IV), Nickel(II), Copper(II), and Palladium(II) Complexes of Tetraazaannulenes

The oxovanadium(IV), nickel(II), copper(II), and palladium(II) complexes of 5,14-dihydrodibenzo-tetraazacyclotetradecine and 7,8,15,16,17,18-hexahydrodibenzotetraazacyclotetradecine have been synthesized, and studied by electronic, vibrational, NMR, ESR, and ESCA spectroscopy.The absorption bands appearing in the energy region greater than 16800 cm-1 were attributed to ?-?* transitions within a ligand molecule and metal to ligand charge-transfer transitions.The ligand-field bands were not assigned for the present complex, because all the ligand-field bands were obscured by the ?->?* and charge-transfer bands of high intensity.The metal complexes assume the square-planar configurations since no significant absorption band was detected in the region below 17000 cm-1.A strong band appearing at ca. 1620 cm-1 was assigned to the C-N stretching mode, and this band was shifted to lower frequency upon metal coordination.A V=O stretching band was observed at ca. 950 cm-1 for the oxovanadium complexes.The oxovanadium, nickel, copper, and palladium complexes showed a single nitrogen 1s peak by ESCA spectroscopy, whereas the metal-free ligand, 5,14-dihydrodibenzotetraazacyclotetradecine, revealed double nitrogen 1s peaks.ESR spectra were measured in xylene-benzene (2:1 v/v) as well as in the corresponding ligand matrices at room temperature.Judging from g tensors, the copper complexes were confirmed to have D2b coordination symmetry with an unpaired electron in the dxy orbital.On the other hand, vanadium(IV) is in C4v coordination symmetry with an unpaired electron in the d orbital.

Non-template Synthesis of 'N4' Macrocyclic Imine Ligands with Variable Ring Sizes: The Importance of Intramolecular Hydrogen-bonding. X-Ray Crystal Structures of Three Macrocyclic and Two Open-chain Ligands

Di-imine tetra-aza macrocycles with an extensive range of ring sizes can be isolated by simple condensations without recourse to 'metal-ion template' or 'high-dilution' reactions, provided the rings can form intramolecular hydrogen bonds to reduce unfavourable lone-pair-lone-pair interactions between the nitrogen atoms.