3343-70-2 Usage
Uses
Used in Metabolic Research:
D-[1-18O]GLUCOSE is used as a tracer in metabolic research for tracking glucose metabolism. The application reason is its ability to provide insights into the metabolic fate of glucose, which is crucial for understanding the role of glucose in various physiological and pathological conditions.
Used in Pharmaceutical and Biomedical Industries:
In the pharmaceutical and biomedical industries, D-[1-18O]GLUCOSE is used as a diagnostic tool for studying the mechanisms of metabolic diseases. The application reason is its capacity to help elucidate the underlying mechanisms of conditions like diabetes, cancer, and obesity, thereby contributing to the development of potential therapeutic interventions.
Used in Clinical Diagnostics:
D-[1-18O]GLUCOSE is utilized as a clinical diagnostic agent for assessing glucose metabolism in patients. The application reason is its potential to offer a non-invasive method for monitoring glucose uptake and utilization, which can be instrumental in diagnosing and managing metabolic disorders.
Used in Nutritional Studies:
In nutritional studies, D-[1-18O]GLUCOSE is employed as a research compound for examining the effects of diet on glucose metabolism. The application reason is its ability to provide data on how different nutrients influence glucose utilization and metabolic pathways, which can inform dietary recommendations and interventions for managing metabolic health.
Check Digit Verification of cas no
The CAS Registry Mumber 3343-70-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,4 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3343-70:
(6*3)+(5*3)+(4*4)+(3*3)+(2*7)+(1*0)=72
72 % 10 = 2
So 3343-70-2 is a valid CAS Registry Number.
3343-70-2Relevant academic research and scientific papers
Clark Jr.,Barker
, p. 253 - 261 (1986)
Synthetic methods are described for enriching 4-, 5-, and 6-carbon aldoses with oxygen isotopes. The general approach includes exchange between H2(1)8O and the aldehyde group of an aldose, exchange of O-1 onto C-2 of both of the 2-epimeric aldoses formed by molybdate-resin epimerization, and chain extension using cyanide addition. These methods make possible the production of all 16 aldohexoses enriched at 5 of the 6 oxygen atoms, all 8 aldopentoses enriched at 4 of the 5 oxygen atoms, and the four aldotetroses enriched at 2 of the 4 oxygen atoms. The general applicability of these methods is illustrated by the synthesis of a group of 22 different, 18O-enriched, biologically important D-aldoses having 4, 5, and 6 carbon atoms. The group includes D-[1-, 2-, 3-, 4-, O]glucose, D-[1-, 2-, 3-, 4-, and 6-18O]mannose, D-[1-, 2-, 3-, and 5-18O]arabinose, D-[1- abd 2- 18O] erythorose, and D-[1- and 2-18O]threose. The g.l.c.-m.s. characterization of these sugars with respect to the position and degree of 18O-enrichment is reported. The potential of the methods for producing aldoses having oxygen labels at multiple positions, or aldoses labeled simultaneously with oxygen, hydrogen, and carbon isotopes is discussed.
