33439-15-5Relevant academic research and scientific papers
Direct access to cobaltacycles via C-H activation: N-chloroamide- enabled room-temperature synthesis of heterocycles
Yu, Xiaolong,Chen, Kehao,Guo, Shan,Shi, Pengfei,Song, Chao,Zhu, Jin
supporting information, p. 5348 - 5351 (2017/11/07)
Cobaltacycle synthesis via C-H activation has been achieved for the first time, providing key mechanistic insight into cobalt catalytic chemistry. NChloroamides are used as a directing synthon for cobalt-catalyzed roomtemperature C-H activation and construction of heterocycles. Alkynes as coupling partners allow convenient access to isoquinolones, a class of synthetically and pharmaceutically important compounds. The broad substrate scope enables a diverse range of substitution patterns to be incorporated into the heterocyclic scaffold.
Preparation of N-chloroamides using trichloroisocyanuric acid
Hiegel, Gene A.,Hogenauer, Tyrone J.,Lewis, Justin C.
, p. 2099 - 2105 (2007/10/03)
Amides are efficiently converted to N-chloroamides by trichloroisocyanuric acid in methanol. Copyright Taylor & Francis, Inc.
Preparation of methyl N-substituted carbamates from amides through N-chloroamides
Hiegel, Gene A.,Hogenauer, Tyrone J.
, p. 2091 - 2098 (2007/10/03)
Amides are chlorinated on the nitrogen using trichloroisocyanuric acid, and the N-chloroamides are then rearranged to the corresponding methyl N-substituted carbamates by sodium methoxide in methanol. Copyright Taylor & Francis, Inc.
