1312991-48-2

Basic information

• Product Name: 6-methyl-3,4-diphenylisoquinolin-1(2H)-one
• Synonyms: 6-methyl-3,4-diphenylisoquinolin-1(2H)-one
• CAS NO: 1312991-48-2
• Molecular Weight: 311.383
• Mol File: 1312991-48-2.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 6-methyl-3,4-diphenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3,4-diphenylisoquinolin-1(2H)-one(1312991-48-2)
• EPA Substance Registry System: 6-methyl-3,4-diphenylisoquinolin-1(2H)-one(1312991-48-2)

Safety Data

• Hazardous Substances Data: 1312991-48-2(Hazardous Substances Data)

Upstream product

• 827624-81-7 4-methyl-N-(methylsulfonyl)benzamide 
• 501-65-5 diphenyl acetylene 
• 343337-70-2 4-methyl-N-((trifluoromethyl)sulfonyl)benzamide 
• 120336-96-1 N-<(4-Methylphenyl)sulfonyl>-4-methylbenzenecarboxamide 
• 36048-78-9 N-(1-pyridinio)-p-toluamidate 
• 1373758-54-3 3-(4-methylphenyl)-5H-1,4,2-dioxazol-5-one 
• 2318-82-3 N-hydroxy-4-methylbenzamide 
• 1530-73-0 4-methyl-N'-(4-methylbenzoyl)benzohydrazide 
• 3619-22-5 p-toluic hydrazide 
• 29336-32-1 N-acetoxy-4-methyl-benzamide 
• 619-55-6 para-methylbenzamide 
• 33439-15-5 N-chloro-p-methylbenzamide 
• 99-94-5 p-Toluic acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 1280681-81-3 C₃₂H₂₅NO₃ 
• 1253388-67-8 11-methyl-5,6,13-triphenyl-8H-dibenzo[a,g]quinolizin-8-one 

Relevant articles and documents

One-Pot Two-Step Double Annulation of N-Methoxybenzamides with Alkynes and Alkenes: Regioselective Construction of Isoindolo[2,1-b]isoquinolin-5(7H)-ones

A one-pot two-step double annulation strategy to produce isoindolo[2,1-b]isoquinolin-5(7H)-ones via the reaction of N-methoxybenzamides with symmetrical/unsymmetrical alkynes and alkenes has been developed, which proceeds through Ru-catalysed unsymmetrica

Synthesis of isoquinolone via rhodium(III)-catalyzed C-H activation with 1,4,2-dioxazol-5-ones as oxidizing directing group

An efficient rhodium-catalyzed direct C-H activation for the synthesis of isoquinolone with 1,4,2-dioxazol-5-ones as oxidizing directing groups have been developed, which featured mild reaction conditions, short reaction time and satisfactory yield.

Redox-Neutral [4 + 2] Annulation of N-Methoxybenzamides with Alkynes Enabled by an Osmium(II)/HOAc Catalytic System

By making use of a direct C-H activation strategy, an efficient osmium(II)-catalyzed redox-neutral [4 + 2] annulation of N-methoxybenzamides with alkynes has been accomplished. Computational and experimental studies revealed that such transformation leading to the synthesis of the isoquinolone core might follow an Os(II)-Os(IV)-Os(II) catalytic pathway, in which an unusual HOAc-assisted oxidative addition of osmium(II) into the N-O bond to generate the osmium(IV) species was involved as one of the key transition states. Further exploration of divergent C-H activation reaction modes enabled by the osmium(II) catalyst has also been exemplified for one-pot assembly of other either linear or cyclic products.