33440-72-1

Upstream product

• 58-27-5 menadione 
• 622-95-7 4-chlorobenzyl bromide 
• 106-43-4 para-chlorotoluene 
• 1878-66-6 4-chlorophenylacetic Acid 
• 104-88-1 4-chlorobenzaldehyde 
• 34082-49-0 3-(α-4-Dichlorbenzyl)-2-methyl-1,4-naphthachinon 

Downstream Products

• 1189395-10-5 2-(4-chloro-benzyl)-1,4-dimethoxy-3-methyl-naphthalene 
• 1189394-72-6 2-(4-chlorobenzoyl)-3-methylnaphthalene-1,4-dione 
• 1189395-12-7 1-(4-tert-butyl-benzyl)-4-[4-(1,4-dimethoxy-3-methyl-naphthalen-2-ylmethyl)-phenyl]-piperazine 
• 1189395-15-0 P_TM₈₇ 
• 33440-79-8 C₃₆H₂₄Cl₂O₄ 

Relevant academic research and scientific papers

Bioinspired Photoredox Benzylation of Quinones

3-Benzylmenadiones were obtained in good yield by using a blue-light-induced photoredox process in the presence of Fe(III), oxygen, and γ-terpinene acting as a hydrogen-atom transfer agent. This methodology is compatible with a wide variety of diversely substituted 1,4-naphthoquinones as well as various cheap, readily available benzyl bromides with excellent functional group tolerance. The benzylation mechanism was investigated and supports a three-step radical cascade with the key involvement of the photogenerated superoxide anion radical.

Iron-catalyzed regioselective alkylation of 1,4-quinones and coumarins with functionalized alkyl bromides

A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.

Metal-free oxidative cross-dehydrogenative coupling of quinones with benzylic C(sp3)-H bonds

A metal-free cross-dehydrogenative coupling of quinones with toluene derivatives has been established. A series of quinones were subjected to reaction with toluene derivatives in the presence of di-tertbutyl peroxide (DTBP) for direct synthesis of benzylq

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites

3-Benzylmenadiones are potent antimalarial agents that are thought to act through their 3-benzoylmenadione metabolites as redox cyclers of two essential targets: the NADPH-dependent glutathione reductases (GRs) of Plasmodium-parasitized erythrocytes and m

1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF

Derivatives of formula (I) wherein A is selected from the following rings: and their preparation and their application as antimalarial agents.