33442-37-4

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 106-49-0 p-toluidine 
• 21646-74-2 1-nitro-2-(4-nitrophenyl)-1-ethoxycarbonylethene 
• 71-43-2 benzene 
• 461670-18-8 ethyl (2RS,3RS)-2-nitro-3-nitro-oxy-3-(4-nitrophenyl)propionate 
• 622-58-2 p-Tolylisocyanate 
• 619-73-8 4-nitrobenzyl chloride 
• 785-80-8 p-nitrobenzylideneaniline 
• 25105-94-6 N-(4-nitrophenylmethylidene)-n-butylamine 
• 39203-82-2 N-(4-cyanobenzylidene)-4-methylaniline 

Downstream Products

• 6421-27-8 bis-[4-(p-tolylimino-methyl)-phenyl]-diazene-N-oxide 
• 25105-94-6 N-(4-nitrophenylmethylidene)-n-butylamine 
• 106-49-0 p-toluidine 
• 785-80-8 p-nitrobenzylideneaniline 
• 38565-12-7 (4-Nitro-phenyl)-p-tolylamino-acetonitrile 
• 16035-83-9 N-(4-nitro-benzyl)-p-toluidine 

Relevant academic research and scientific papers

Substituent effects on the mesogenic benzylidenes of 4-methylaniline: Synthesis, characterization, DFT, NLO, photophysical, molecular docking, and antibacterial studies

Substituted benzylidene anilines forming donor-π-acceptor (D-π-A) molecular systems are the models of molecular mesogenic cores for NLO applications. The effect of the benzylidene substituents on the sensitivity of the electronic properties of the azometh

Synthesis of Green/Blue Light Emitting Quinolines by Aza-D-A Reaction Using InCl3 Catalyst

An efficient InCl3-catalyzed sequential reaction of aromatic amines, aromatic aldehydes and functionalized alkynes leading to the formation of new quinoline derivatives exhibiting significant fluorescence activities is described. The photophysi

Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors

Imine functionality is found in many compounds with important biological activity. Thus, the development of novel synthetic approaches for imines is important. In this work, it is propose an easy, eco-friendly and straightforward synthesis pathway of aryl imines under microwave irradiation catalyzed by Alumina-sulfuric acid. In addition, the in vitro enzymatic inhibition, antioxidant activity and molecular docking studies were performed. The aryl imines were isolated with yields in the range of 37–94%. All aryl imines synthesized were evaluated for in vitro inhibitory potential against α-glucosidase and α-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes. The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against α-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against α-glucosidase. The molecular docking studies in α-glucosidase and α-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent. The docking analysis reveals these synthetic aryl imines 3d-i interact in same active site than acarbose drug in both enzymes.

Observation of the complex spectra for the supramolecular system involving silver nanoparticles-biaryl Schiff bases containing the nitro group

A series of biaryl Schiff bases containing the nitro groups, 4-XArCH═NArNO2-4′ (XBANO2-4′) and 4-NO2ArCH═NArY-4′ (4-NO2BAY), were synthesized. Also, the fish sperm DNA (fsDNA) and silver nanoparticles (AgNPs) solutions were prepared. By mixing these compounds with fsDNA or AgNPs solution and determining the ultraviolet absorption spectra of the mixture solutions, an interesting phenomenon was found: a new absorption peak λmax,lim appeared in the (XBANO2-4′)-AgNPs solution, which was longer than the wavelength of λmax of XBANO2-4′ solution. The new absorption peak in the (XBANO2-4′)-AgNPs solution was the complex spectrum originating from the electron transfer between XBANO2-4′ and AgNPs. Whereas this phenomenon was not observed in the (4-NO2BAY)-AgNPs solutions, a quantitative correlation analysis was carried out with the measured spectral data, and the results show that the wave number νmax,lim of the λmax,lim is mainly affected by the excited-state substituent constant (Formula presented.) rather than the ground Hammett constant σ of the X group. The redshift magnitude Δνmax,WSL, namely, Δνmax,WSL = (1/λmax) ? (1/λmax,lim), of the wavelength λmax,lim is related to the highest occupied molecular orbital and lowest unoccupied molecular orbital of XBANO2-4′. The discovery of this new phenomenon is helpful to understanding the interaction between AgNPs-organic compound supramolecular systems.

Dehydrogenation and α-functionalization of secondary amines by visible-light-mediated catalysis

A visible-light-mediated process for dehydrogenation of amines has been described. The given protocol showed a broad substrate scope, mild reaction conditions and excellent results without the requirement of tedious purification. This process can be applied in one-pot functionalization of secondary amines with various nucleophiles through the cooperation of visible-light and Lewis acid catalysis, leading to the structurally varied essential components of biologically active molecules. In addition, Stern-Volmer studies and quenching experiments revealed the role of a catalyst and led to the proposed mechanism of this transformation.

Systematic studies on mechanochemical synthesis: Schiff bases from solid aromatic primary amines and aldehydes

A versatile and robust mechanochemical route to Aldehyde–Schiff base conversions has been established for a broad range of aldehydes via a simple cogrinding in mortar with a pestle under a solvent-free, as well as solvent-assisted, environment. The extent

Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies

Schiff base derivatives were synthesized in this study via conventional, microwave irradiation and ultrasound sonication methods. Optimization conditions were examined for several parameter such as solvent, reaction time and yield. After determining the o

FeCl3-Mediated One-Pot Cyclization–Aromatization of Anilines, Benzaldehydes, and Phenylacetylenes under Ball Milling: A New Alternative for the Synthesis of 2,4-Diphenylquinolines

A straightforward and efficient method has been developed for the solvent-free synthesis of 2,4-diphenylquinolines via a one-pot reaction of anilines, benzaldehydes, and phenylacetylenes promoted by FeCl3 under solvent-free mechanochemical ball

Dual Heterogeneous Catalyst Pd-Au@Mn(II)-MOF for One-Pot Tandem Synthesis of Imines from Alcohols and Amines

A new Mn(II) metal-organic framework (MOF) 1 was synthesized by the combination of 4,4,4-trifluoro-1-(4-(pyridin-4-yl)phenyl)butane-1,3-dione (L) and Mn(OAc)2 in solution. 1 features a threefold-interpenetrating NbO net containing honeycomb-like channels, in which the opposite Mn(II)···Mn(II) distance is 23.5075(10) ?. Furthermore, 1 can be an ideal platform to support Pd-Au bimetallic alloy nanoparticles to generate a composite catalytic system of Pd-Au@Mn(II)-MOF (2). 2 can be a highly active bifunctional heterogeneous catalyst for the one-pot tandem synthesis of imines from benzyl alcohols and anilines and from benzyl alcohols and benzylamines.

Azetidinone derivatives and its preparation method and application

The invention discloses azacyclobutanone derivatives which are compounds as shown in the formula (I) and medicinal salts thereof. The invention further discloses a preparation method and application of the azacyclobutanone derivatives. The azacyclobutanone derivatives disclosed by the invention can be used for treating or preventing atherosclerosis or lowering plasma cholesterol level, and has strong plasma cholesterol reducing activity and wide market prospect.