334477-36-0 Usage
Uses
Used in Pharmaceutical Industry:
2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE is used as a building block for the synthesis of various drugs and pharmaceutical intermediates. Its presence in the molecular structure of these compounds can contribute to their therapeutic effects and properties.
Used in Organic Synthesis:
2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE is used as a reagent for its ability to introduce the trifluoromethyl group into organic molecules. This can enhance the reactivity and stability of the resulting compounds, making it a useful tool in the synthesis of complex organic molecules.
Used in Medicinal Chemistry Research:
2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE is used as a valuable tool in research due to its unique chemical properties. It aids in the exploration of new drug candidates and the understanding of molecular interactions within biological systems.
Used in Chemical Biology:
2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE is employed in chemical biology to study the interactions between small molecules and biological targets. Its trifluoromethyl groups can influence the binding affinity and selectivity of the compound towards specific biological molecules, making it a useful probe in this field.
Check Digit Verification of cas no
The CAS Registry Mumber 334477-36-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,4,4,7 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 334477-36:
(8*3)+(7*3)+(6*4)+(5*4)+(4*7)+(3*7)+(2*3)+(1*6)=150
150 % 10 = 0
So 334477-36-0 is a valid CAS Registry Number.
334477-36-0Relevant academic research and scientific papers
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists
Sabbatini, Fabio M.,Fabio, Romano Di,Griffante, Cristiana,Pentassuglia, Giorgio,Zonzini, Laura,Melotto, Sergio,Alvaro, Giuseppe,Capelli, Anna M.,Pippo, Lara,Perdona', Elisabetta,Denis, Yves St.,Costa, Silvano,Corsi, Mauro
scheme or table, p. 623 - 627 (2010/06/12)
A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK1 antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model.
