334477-35-9Relevant academic research and scientific papers
Enantioselective Imine Reduction Catalyzed by Phosphenium Ions
Lundrigan, Travis,Welsh, Erin N.,Hynes, Toren,Tien, Chieh-Hung,Adams, Matt R.,Roy, Kayelani R.,Robertson, Katherine N.,Speed, Alexander W. H.
supporting information, p. 14083 - 14088 (2019/10/11)
The first use of phosphenium cations in asymmetric catalysis is reported. A diazaphosphenium triflate, prepared in two or three steps on a multigram scale from commercially available materials, catalyzes the hydroboration or hydrosilylation of cyclic imin
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists
Sabbatini, Fabio M.,Fabio, Romano Di,Griffante, Cristiana,Pentassuglia, Giorgio,Zonzini, Laura,Melotto, Sergio,Alvaro, Giuseppe,Capelli, Anna M.,Pippo, Lara,Perdona', Elisabetta,Denis, Yves St.,Costa, Silvano,Corsi, Mauro
scheme or table, p. 623 - 627 (2010/06/12)
A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK1 antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model.
