33449-75-1

Upstream product

• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 30839-20-4 1,4-bis(4-methoxyphenyl)-2,3-diphenylbutane-1,4-dione 

Relevant academic research and scientific papers

Silver-Catalyzed Coupling of Two Csp3-H Groups and One-Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles

Silver-catalyzed coupling of two Csp3-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization to synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as the terminal oxidant and readily accessible starting materials, displays a wide substrate scope and broad functional-group tolerance.