1023-17-2Relevant articles and documents
Construction of a novel asymmetric imidazole-cored AIE probe for ratiometric imaging of endogenous leucine aminopeptidase
Feng, Bin,Hu, Yibo,Huang, Shuai,Huang, Xueyan,Lei, Qian,Zeng, Hongliang,Zeng, Qinghai,Zeng, Wenbin
, p. 6608 - 6611 (2021)
We report a rational strategy to deliberately construct the first asymmetric tetraarylimidazole-based AIE probe, integrating AIE behavior in synergy with ESIPT character to image endogenous LAP for the first time. It offered good sensitivity and selectivity, and concomitantly, was applied successfully for real-time tracking of LAP in the cisplatin-induced liver injury zebrafish model.
Induced osteoblast differentiation by amide derivatives of stilbene: The possible osteogenic agents
Bawankule, Dnyaneshwar U.,Gupta, Atul,Imran Ahamad, Mohd.,John, Aijaz A,Khan, Feroz,Luqman, Suaib,Prakash, Ravi,Singh, Divya,Wani, Zahoor,Yadav, Deepika
, (2020)
A series of amide derivatives of stilbene was synthesized and investigated for osteogenic activity. Out of sixteen, seven compounds viz 19c, 19g, 19i, 24b, 25a, 25c and 26a showed significant osteoblast differentiation within 1 pM–1 μM concentrations. Amongst all, 26a was identified as most active molecule which presented effective mineralization of osteoblasts and expression of mRNA of osteogenic marker gene such as BMP-2, ALP, and Runx-2 at 1 pM. In estrogen-deficient balb/c mice, 26a showed significant osteogenic activity at 5 mg-kg?1 body weight dose. The protein expression study for estrogen receptors α and β (ER-α & ER-β) using mouse calvarial osteoblasts (MCOs) and molecular docking analyses showed preferential expression of ER-β by 26a indicating the possibility of ER-β mediated osteogenic activity of 26a.
Highly efficient p-toluenesulfonic acid-catalyzed alcohol addition or hydration of unsymmetrical arylalkynes
Olivi, Nathana?l,Thomas, Emmanuel,Peyrat, Jean-Fran?ois,Alami, Mouad,Brion, Jean-Daniel
, p. 2175 - 2179 (2004)
Under a catalytic amount of PTSA in aqueous or alcoholic media, activated unsymmetrical arylalkynes 1 undergo regioselective water or alcohol addition to afford successfully carbonyl compounds 2 in good to excellent yields. This new environmentally metal-free procedure, which afforded only Markovnikov adducts, is characterized by the mildness of acidic conditions and the excellent regio- and chemoselectivity.
Palladium/copper tandem catalysis for carbon-carbon triple bond cleavage of diaryl acetylenes
Wang, Zhiwei,Fan, Wenyou,Deng, Guo-Jun,Zhou, Wang
, p. 5449 - 5452 (2015)
A method for carbon-carbon triple bond cleavage based on palladium/copper tandem catalysis is developed. In this chemistry, anilines and diaryl acetylenes were converted into benzamides through cascade transformations combining palladium-catalyzed hydroamination of alkyne with copper-catalyzed aerobic oxidative C-C bond cleavage.
Acylation of aromatic compounds using moisture insensitive InCl3 impregnated mesoporous Si-MCM-41 catalyst
Choudhary, Vasant R.,Jana, Suman K.,Patil, Nilesh S.
, p. 1105 - 1107 (2002)
Acylation of aromatic compounds (benzene, toluene, p-xylene, mesitylene, anisole, naphthalene, methylnaphthalene and methoxynaphthalene) by an acyl chloride (benzoyl chloride, phenylacetyl chloride, propionyl chloride or butyryl chloride) in high yield, in a short reaction period (3 h), even in the presence of moisture in the aromatic substrate or solvent (dichloroethane), can be accomplished at low temperature (80±1°C) using an InCl3 impregnated Si-MCM-41 catalyst in low catalyst concentration.
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Buck,Ide
, p. 3012 (1932)
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Acylation of aromatic compounds using moisture insensitive mesoporous Si-MCM-41 supported Ga2O3 catalyst
Choudhary, Vasant R.,Jana, Suman K.
, p. 2843 - 2848 (2002)
Mesoporous Si-MCM-41 supported Ga2O3 is a highly active catalyst for the acylation of aromatic compounds with different acyl chlorides. Moreover, this catalyst is not deactivated by water and hence does not require moisture-free reaction conditions.
Addition of arylboronic acids to nitriles in aqueous media catalyzed by a 2,2′-bipyridine-cyclopalladated ferrocenylimine complex
Yu, Ajuan,Li, Jingya,Cui, Mengjun,Wu, Yangjie
, p. 3063 - 3067 (2007)
The addition of arylboronic acids to nitriles catalyzed by a bipyridine-cyclopalladated ferrocenylimine complex in aqueous media was developed. The reactions could be conducted under acidic or basic conditions in aqueous media. The addition of NH4Cl was found to have a drastic effect on the reaction yields. Georg Thieme Verlag Stuttgart.
Nafion/silica composite material reveals high catalytic potential in acylation reactions
Heidekum, Alfred,Harmer, Mark A.,Hoelderich, Wolfgang F.
, p. 230 - 232 (1999)
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Teich,Curtin
, p. 2796 (1950)
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Jenkins
, p. 703,704, 2896, 2897 (1933)
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Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones
Tan, Yu-Fang,Chen, Yuan,Li, Rui-Xue,Guan, Zhi,He, Yan-Hong
supporting information, (2021/12/21)
Electrochemical oxidation-induced direct carbonylation of benzyl C–H bond for the synthesis of aromatic α-diketones is described. In this process, tetrabutylammonium iodide (nBu4NI) not only acts as an electrolyte, but its iodine anion is oxidized to an iodine radical at the anode, acting as a hydrogen atom transfer agent. The iodine radical extracts the benzyl hydrogen atom and causes the carbonylation of the benzyl position, where O2 in the air is used as an oxygen source.
H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water
Luo, Mengqiang,Zhang, Yaohong,Fang, Ping,Li, Yan,Qi, Chenze,Li, Yong,Shen, Runpu,Cheng, Kai,Wang, Hai
supporting information, p. 630 - 635 (2022/02/01)
An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.
