334542-44-8 Usage
General Description
4-Chloro-2-(methylsulfanyl)pyridine is a chemical compound that belongs to the organic class of aromatic heteromonocyclic compounds. Although it is granted with a PubChem CID of 3013224, its chemical abstracts service (CAS) number is not designated. 4-Chloro-2-(methylsulfanyl)pyridine is pallidly coloured and has a low molar mass of about 159.635 g/mol. It is constituted of carbon, hydrogen, nitrogen, sulfur, and chlorine elements that form the molecular formula C6H6ClNS. 4-Chloro-2-(methylsulfanyl)pyridine is typically utilised in the field of chemistry due to its complex structure and distinct chemical attributes. However, its efficacy, safety, physical and chemical properties, potential health impacts, and environmental effects are not well-studied or documented.
Check Digit Verification of cas no
The CAS Registry Mumber 334542-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,4,5,4 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 334542-44:
(8*3)+(7*3)+(6*4)+(5*5)+(4*4)+(3*2)+(2*4)+(1*4)=128
128 % 10 = 8
So 334542-44-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClNS/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3
334542-44-8Relevant articles and documents
TMSCH2Li-LiDMAE: a new nonnucleophilic reagent for C-2 lithiation of halopyridines
Doudouh, Abdelatif,Gros, Philippe C.,Fort, Yves,Woltermann, Christopher
, p. 6166 - 6171 (2007/10/03)
A new superbasic reagent has been discovered by combining TMSCH2Li and LiDMAE in hexane. This reagent was found highly efficient for the C-2 lithiation of sensitive chloro- and fluoropyridines. The metallation occurred chemo- and regioselectively at 0 °C avoiding the nucleophilic addition or substrate degradation commonly obtained with other alkyllithiums even at lower temperatures.
First regioselective c-2 lithiation of 3- and 4-chloropyridines
Choppin, Sabine,Gros, Philippe,Fort, Yves
, p. 603 - 606 (2007/10/03)
We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.
