33456-61-0

Basic information

• Product Name: Pyrimidine, 2,4-dimethyl-, 1-oxide (8CI,9CI)
• Synonyms: Pyrimidine, 2,4-dimethyl-, 1-oxide (8CI,9CI)
• CAS NO: 33456-61-0
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14052
• Product Categories: PYRIMIDINE
• Mol File: 33456-61-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 271.0±33.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 3.39±0.20(Predicted)
• CAS DataBase Reference: Pyrimidine, 2,4-dimethyl-, 1-oxide (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2,4-dimethyl-, 1-oxide (8CI,9CI)(33456-61-0)
• EPA Substance Registry System: Pyrimidine, 2,4-dimethyl-, 1-oxide (8CI,9CI)(33456-61-0)

Safety Data

• Hazardous Substances Data: 33456-61-0(Hazardous Substances Data)

Upstream product

• 14331-54-5 2,4-dimethylpyrimidine 

Relevant articles and documents

Synthesis of some pyrimidine N-oxides

Various monosubstitudes pyrimidines and methylpyrimidines were N-oxidized with a number of different peracids.In general, they are more susceptible to side reactions accompanying N-oxidation (i.e., decomposition, annular carbon oxidation, ring opening) than other ?-deficient diazine and triazine analogs.Unsymmetrical pyrimidines, which can potentially yield two isomeric products, were N-oxidized preferentially at the site para to strong electron-donating substituents.Weaker ringactivating groups, such as methyl, are mainly ortho directing and only aid in the N-oxidation of pyrimidine nuclei having ortho/para-directing substituents.

OXIDATION OF 2,4-DISUBSTITUTED PYRIMIDINES WITH ORGANIC PERACIDS

While 4,6-disubstituted (alkyl, aryl, alkoxyl) pyrimidines easily afforded the corresponding mono-N-oxides with hydrogen peroxide in glacial acetic acid, pyrimidine derivatives whose 6-position is free, are partly oxidatively degradated during N-oxidation reaction.The oxidation of the latter compounds under the above conditions gave 2,4-disubstituted imidazoles together with their mono-N-oxides.A likely mechanism of this ring-contraction and the improved conditions for the synthesis of the N-oxides are also described.