14331-54-5

Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 2,4-dimethyl(6CI,7CI,8CI,9CI) is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the design of new drugs, potentially leading to the development of novel therapeutic agents.
Used in Agrochemical Industry:
Pyrimidine, 2,4-dimethyl(6CI,7CI,8CI,9CI) is also used as a building block in the synthesis of agrochemicals. Its incorporation into the development of new agrochemicals can contribute to the creation of more effective and targeted pest control solutions.
Used in Organic Chemistry Research and Development:
Pyrimidine, 2,4-dimethyl(6CI,7CI,8CI,9CI) is utilized in research and development within the field of organic chemistry. Its unique properties and potential reactivity make it a valuable compound for exploring new chemical reactions and syntheses, further expanding the understanding of organic chemistry and its applications.

InChI:InChI=1/C6H8N2/c1-5-3-4-7-6(2)8-5/h3-4H,1-2H3

Upstream product

• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 5744-65-0 1,1,3,3-tetramethoxy-butane 
• 124-42-5 acetamidine hydrochloride 
• 75-05-8 acetonitrile 
• 74-86-2 acetylene 
• 289-95-2 PYRIMIDINE 
• 75-91-2 tert.-butylhydroperoxide 
• 64-19-7 acetic acid 
• 67-68-5 dimethyl sulfoxide 
• 3438-46-8 4-Methylpyrimidine 
• 5053-43-0 2-methylpyrimidine 
• 930-61-0 2,4-dimethyl-2-imidazoline 
• 67-66-3 chloroform 
• 74356-36-8 2,4-dimethylpyrimidine-5-carboxylic acid 

Downstream Products

• 33342-84-6 2,6-dimethylpyrimidine 1-oxide 
• 54198-75-3 (2,6-dimethylpyrimidin-4-yl)methanol 
• 92675-48-4 2-methyl-4(E)-styrylpyrimidine 
• 73937-21-0 4-acetyl-2,6-dimethylpyrimidine 
• 33456-61-0 2,4-Dimethylpyrimidine 1-oxide 
• 92675-49-5 2-methyl-4-phenethylpyrimidine 
• 89966-96-1 4-methoxymethyl-2-methylpyrimidine 
• 89967-01-1 4-(chloromethyl)-2-methylpyrimidine 
• 13036-57-2 2-chloro-4-methylpyrimidine 
• 15966-49-1 1-Hydroxybenzimidazol-3-oxid 
• 1632-74-2 3,6-dimethylpyridazine 
• 694-81-5 4,5-dimethylpyrimidine 
• 108-50-9 2,6-dimethylpyrazine 

Relevant academic research and scientific papers

Vapor phase phototransposition chemistry of dimethylpyrazines and dimethylpyrimidines

Based on their phototransposition chemistry, the three dimethylpyrazines and four dimethylpyrimidines can be arranged into two groups. 2,5-Dimethylpyrazine, 2,5-dimethylpyrimidine, and 4,6-dimethylpyrimidine constitute a photochemical triad. Irradiation of any one member of the triad in the vapor phase results in the formation of the other two members. The other four isomers, 2,6-dimethylpyrazine, 2,3-dimethylpyrazine, 2,4- dimethylpyrimidine, and 4,5-dimethylpyrimidine constitute a photochemical tetrad. Irradiation of any one member results in the formation of the other three. In addition, 2,4-dimethylpyrimidine and 2,6-dimethylpyrazine also photoisomerize to 3,6-dimethylpyridazine. Irradiation of the last in the vapor state resulted in the four members of the tetrad.

MEDICINAL COMPOSITIONS

The present invention relates to an agent for the prophylaxis or treatment of pain, an agent for suppressing activation of osteoclast, and an inhibitor of osteoclast formation, which contains a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor.

One-pot synthesis of pyridines or pyrimidines by tandem oxidation-heteroannulation of propargylic alcohols

Pyridines and pyrimidines are prepared in a single step from propargylic alcohols by in situ oxidation with o-iodoxybenzoic acid or manganese dioxide and reaction with enamines or amidines, respectively, under either thermal or microwave-assisted conditions in a new one-pot tandem oxidation-heteroannulation procedure. The reaction of a β-ketoester, propargylic alcohol and ammonium acetate, with in situ oxidation, constitutes a highly facile three-component reaction for the synthesis of pyridines that accomplishes four distinct synthetic operations in one-pot, good yield and with total regiocontrol.

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.

Trialkylalanes in palladium-catalyzed C-alkylations of azines

Carbo-substitution with alkyl groups in halogenoazines is readily effected under the influence of Pd-catalysis with alanes as the donor of the alkyl group. Acta Chemica Scandinavica 1997.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.

POLAR EFFECTS IN THE HOMOLYTIC METHYLATION OF PYRIMIDINE: ORIENTATION AND POLYSUBSTITUTION

The homolytic methylation of pyrimidine in aqueous solution has been investigated with three different radical sources: tBuOOH-Fe(2+), MeCO2H-S2O8(2-)-Ag(1+), and MeSOMe-H2O2-Fe(2+).This last reagent, used for the first time in homolytic aromatic substitution, turned out to be the most efficient.The orientation of mono- and poly-methylated derivatives is discussed on the basis of polar effects.

Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

The vapor-phase reactions of imidazolines and anils with chloroform at 550 deg C are compared with their liquid-phase reactions in the presence of hexachloroacetone and base or upon thermolysis with trichloroacetate ion.In the vapour-phase reactions imidazolines, unlike imidazoles, gave non-chlorinated pyrimidines, and 1-methyl-imidazole gave 2-cyanopyrrole and the four 3-chlorocyanopyridines.