14331-54-5

Basic information

• Product Name: Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI)
• Synonyms: Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI);2,4-Dimethylpyrimidine;PyriMidine, 2,4-diMethyl-
• CAS NO: 14331-54-5
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• Product Categories: PYRIMIDINE
• Mol File: 14331-54-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: -2°C
• Boiling Point: 150.55°C
• Flash Point: 36.7°C
• Appearance: /
• Density: 1.1680
• Vapor Pressure: 4.72mmHg at 25°C
• Refractive Index: 1.4880
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI)(14331-54-5)
• EPA Substance Registry System: Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI)(14331-54-5)

Safety Data

• Hazardous Substances Data: 14331-54-5(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 2,4-dimethyl is a chemical compound with the formula C6H8N2. It is a derivative of the heterocyclic compound pyrimidine, which consists of a six-membered ring containing four carbon atoms and two nitrogen atoms. The presence of two methyl groups at the 2 and 4 positions of the pyrimidine ring gives this compound its specific name. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals, as well as in research and development in the field of organic chemistry. Pyrimidine, 2,4-dimethyl is also a potential carcinogenic and mutagenic compound, and its handling and use should be carefully controlled in laboratory and industrial settings.

InChI:InChI=1/C6H8N2/c1-5-3-4-7-6(2)8-5/h3-4H,1-2H3

Upstream product

• 4472-45-1 4-chloro-2,6-dimethylpyrimidine 
• 5744-65-0 1,1,3,3-tetramethoxy-butane 
• 124-42-5 acetamidine hydrochloride 
• 75-05-8 acetonitrile 
• 74-86-2 acetylene 
• 3438-46-8 4-Methylpyrimidine 
• 75-91-2 tert.-butylhydroperoxide 
• 7732-18-5 water 
• 46118-95-0 (4-methyl-pyrimidin-2-ylsulfanyl)-acetic acid 
• 544-97-8 dimethyl zinc(II) 
• 108-50-9 2,6-dimethylpyrazine 
• 5910-89-4 2,3-dimethylpyrazine 
• 2226-86-0 ethyl 2,4-dimethylpyrimidine-5-carboxylate 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 

Downstream Products

• 33342-84-6 2,6-dimethylpyrimidine 1-oxide 
• 54198-75-3 (2,6-dimethylpyrimidin-4-yl)methanol 
• 92675-48-4 2-methyl-4(E)-styrylpyrimidine 
• 73937-21-0 4-acetyl-2,6-dimethylpyrimidine 
• 33456-61-0 2,4-Dimethylpyrimidine 1-oxide 
• 15966-49-1 1-Hydroxybenzimidazol-3-oxid 
• 1632-74-2 3,6-dimethylpyridazine 
• 694-81-5 4,5-dimethylpyrimidine 
• 108-50-9 2,6-dimethylpyrazine 
• 13036-57-2 2-chloro-4-methylpyrimidine 
• 89967-01-1 4-(chloromethyl)-2-methylpyrimidine 
• 89966-96-1 4-methoxymethyl-2-methylpyrimidine 
• 92675-49-5 2-methyl-4-phenethylpyrimidine 

Relevant articles and documents

Vapor phase phototransposition chemistry of dimethylpyrazines and dimethylpyrimidines

Based on their phototransposition chemistry, the three dimethylpyrazines and four dimethylpyrimidines can be arranged into two groups. 2,5-Dimethylpyrazine, 2,5-dimethylpyrimidine, and 4,6-dimethylpyrimidine constitute a photochemical triad. Irradiation of any one member of the triad in the vapor phase results in the formation of the other two members. The other four isomers, 2,6-dimethylpyrazine, 2,3-dimethylpyrazine, 2,4- dimethylpyrimidine, and 4,5-dimethylpyrimidine constitute a photochemical tetrad. Irradiation of any one member results in the formation of the other three. In addition, 2,4-dimethylpyrimidine and 2,6-dimethylpyrazine also photoisomerize to 3,6-dimethylpyridazine. Irradiation of the last in the vapor state resulted in the four members of the tetrad.

One-pot synthesis of pyridines or pyrimidines by tandem oxidation-heteroannulation of propargylic alcohols

Pyridines and pyrimidines are prepared in a single step from propargylic alcohols by in situ oxidation with o-iodoxybenzoic acid or manganese dioxide and reaction with enamines or amidines, respectively, under either thermal or microwave-assisted conditions in a new one-pot tandem oxidation-heteroannulation procedure. The reaction of a β-ketoester, propargylic alcohol and ammonium acetate, with in situ oxidation, constitutes a highly facile three-component reaction for the synthesis of pyridines that accomplishes four distinct synthetic operations in one-pot, good yield and with total regiocontrol.

Bio-organometallic organosulfur chemistry. Transition metal-catalyzed cross-coupling using coenzyme M or thioglycolic acid as the leaving group [2]

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