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33458-27-4

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33458-27-4 Usage

General Description

5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, ethyl ester, also known as ethyl 3,4-dihydro-2-oxopyrimidine-5-carboxylate, is a chemical compound with the molecular formula C8H10N2O3. 5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, ethyl ester is an ethyl ester derivative of 3,4-dihydro-2-oxopyrimidine-5-carboxylic acid and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white solid with a molecular weight of 182.17 g/mol and a melting point of 76-78°C. 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2-oxo-, ethyl ester is a versatile intermediate in organic synthesis and has applications in the production of various chemical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 33458-27-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 33458-27:
(7*3)+(6*3)+(5*4)+(4*5)+(3*8)+(2*2)+(1*7)=114
114 % 10 = 4
So 33458-27-4 is a valid CAS Registry Number.

33458-27-4Relevant articles and documents

COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY

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Paragraph 0088; 0090, (2020/04/09)

The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

PURINYL-N-HYDROXYL PYRIMIDINE FORMAMIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

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, (2018/03/25)

The Invention relates to the field of chemical medicines, and particularly to a purinyl-N-hydroxyl pyrimidine formamide derivative, preparation methods and uses thereof. The Invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative with a st

Phosphoinositide 3-kinase inhibitor with a zinc binding moiety

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Page/Page column 33; 34, (2016/02/26)

The invention provides a compound of Formula I, Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.

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