763-69-9

Usage

Uses

Used in Coatings Industry:
Ethyl-3-ethoxypropanoate is used as a solvent in the coatings industry for its ability to dissolve various substances, contributing to the production of high-quality coatings with desired properties.
Used in Printing Inks Industry:
In the printing inks industry, Ethyl-3-ethoxypropanoate is used as a solvent to facilitate the dispersion of pigments and other components, resulting in improved ink performance and print quality.
Used in Adhesives Industry:
Ethyl-3-ethoxypropanoate is used as a solvent in the adhesives industry to enhance the adhesive's bonding properties and improve its overall performance.
Used in Cosmetics and Personal Care Products:
Ethyl-3-ethoxypropanoate is used in the manufacture of cosmetics and personal care products, where it serves as a solvent to dissolve active ingredients, fragrances, and other components, ensuring a consistent and effective final product.
Safety Considerations:
While Ethyl-3-ethoxypropanoate is considered relatively safe, it is important to handle and store it with care due to its flammable nature. Overexposure to Ethyl-3-ethoxypropanoate can cause irritation to the skin, eyes, and respiratory tract, necessitating proper safety measures during its use.

InChI:InChI=1/C7H14O3/c1-3-9-6-5-7(8)10-4-2/h3-6H2,1-2H3

Synthetic route

ethanol (64-17-5) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With quaternary ammonium salt anion exchange resin In water at 30℃; for 4h; Temperature; Inert atmosphere;	98%
With triethylamine at 20℃; for 8h; Reagent/catalyst; Large scale;	98%
With aluminum oxide; potassium fluoride In acetonitrile at 20℃; for 18h; Michael addition reaction;	90%

sodium ethanolate (141-52-6) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
In ethanol at 40℃; for 3h; Inert atmosphere;	97.6%

formaldehyde diethyl acetal (462-95-3) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With sulfuric acid; acetic anhydride	92%

potassium ethoxide (917-58-8) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With 10H-phenothiazine In methanol at 40 - 100℃; for 2h;	86%

ethanol (64-17-5) + 2-methylenebutyric acid (3586-58-1) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With 10H-phenothiazine; potassium ethoxide at 40 - 80℃; for 2h; Reagent/catalyst;	86%

ethyl 2-bromo-3-ethoxypropanoate (78097-85-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With sodium diethyl phosphate for 5h; Ambient temperature;	72%

sodium ethanolate (141-52-6) + hexyl-methyl-ketone (111-13-7) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9) + 4-pentyl-1,3-cyclohexanedione (63649-30-9)

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h;	A 30% B 58%

acetone (67-64-1) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9) + ethyl 3-(2,4-dioxocyclohexyl)propanoate (1335209-87-4) + 1,3-cylohexanedione (504-02-9)

Conditions	Yield
With sodium hydride In toluene at -10 - 20℃; for 2h; Michael-Claisen cyclization; Inert atmosphere; regioselective reaction;	A 8% B 54% C 3%
With sodium hydride at -10 - 20℃; for 0.0833333h; Michael-Claisen cyclization; Inert atmosphere; neat (no solvent); regioselective reaction;	A 6% B 39% C 9%

2-(2'-Ethoxycarbonylethyl)-saccharin (83747-24-4) + sodium ethanolate (141-52-6) → ethyl 3-ethoxypropionate (763-69-9) + saccharin (81-07-2)

Conditions	Yield
In ethanol Heating;	A n/a B 50%

β-Propiolactone (57-57-8) + ethanol (64-17-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With sulfuric acid
(i), (ii) (esterification); Multistep reaction;

Ethyl 3-bromopropionate (539-74-2) + sodium ethanolate (141-52-6) → ethyl 3-ethoxypropionate (763-69-9)

ethyl 3-iodopropanoate (6414-69-3) + sodium ethanolate (141-52-6) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With diethyl ether

sodium ethanolate (141-52-6) + ethyl 3-chloropropanoate (623-71-2) → ethyl 3-ethoxypropionate (763-69-9)

ethanol (64-17-5) + 3-(ethoxy)propionitrile (2141-62-0) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With sulfuric acid
With sulfuric acid

formaldehyde diethyl acetal (462-95-3) + bromo(2-ethoxy-2-oxoethyl)zinc (5764-82-9) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With acetyl chloride

ethanol (64-17-5) + 1,1,1-trichloro-3-ethoxy-propane (89181-45-3) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With potassium hydroxide

ethanol (64-17-5) + 3-Bromo-propionimidic acid ethyl ester; hydrochloride → ethyl 3-ethoxypropionate (763-69-9)

3-phenoxypropionic acid ethyl ester (22409-91-2) + sodium ethanolate (141-52-6) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
In ethanol

ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With tetraethylammoniumcyanide In acetonitrile

methyl vinyl ketone (78-94-4) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In dichloromethane	70 % Chromat.

ethanol (64-17-5) + ethyl acrylate (140-88-5) → 4-oxopimelate (6317-49-3) + ethyl 3-ethoxypropionate (763-69-9) + Ethyl propionate (105-37-3) + 4-Ethoxycarbonyl-4-methyl-5-oxo-octanedioic acid diethyl ester

Conditions	Yield
With potassium tetracarbonylhydridoferrate at 70℃; for 30h;	A 3 mmol B 3 mmol C 27 mmol D n/a
With potassium tetracarbonylhydridoferrate at 70℃; for 30h;	A n/a B 3 mmol C 27 mmol D 3 mmol

ethanol (64-17-5) + ethyl acrylate (140-88-5) → 4-oxopimelate (6317-49-3) + ethyl 3-ethoxypropionate (763-69-9) + Ethyl propionate (105-37-3) + Diethyl methylmalonate (609-08-5)

Conditions	Yield
With potassium tetracarbonylhydridoferrate at 70℃; for 30h; Product distribution; time, atmosphere;

sodium ethanolate (141-52-6) + ethyl acrylate (140-88-5) → ethyl 3-ethoxypropionate (763-69-9) + α-methylene-glutaric acid diethyl ester

Conditions	Yield
at 80 - 100℃; und Behandeln mit kalter verd.Saeure;

ethyl nitrite (109-95-5) + 3-amino-propionic acid-hydrochloride → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
With ethanol at 95 - 105℃; unter Druck;

ethanol (64-17-5) + ethyl acrylate (140-88-5) → ethyl 3-ethoxyacrylate (1001-26-9) + ethyl 3-ethoxypropionate (763-69-9) + ethyl 3,3-diethoxypropanoate (10601-80-6)

Conditions	Yield
With carbon dioxide; oxygen; copper(l) chloride; dichloro bis(acetonitrile) palladium(II) at 40℃; under 97507.8 Torr; for 12h;	A 6.0 % Chromat. B 5.6 % Chromat. C 75.8 % Chromat.

ethanol (64-17-5) + 3-hydroxypropionic acid (503-66-2) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
sodium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.
calcium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.
magnesium hydroxide In water at 220℃; under 2585.81 Torr; for 1.6h; Product distribution / selectivity;	5 - 50 %Chromat.

3-bromo-1,1,1-trichloro-3-ethoxy-propane (89180-39-2) → ethyl 3-ethoxypropionate (763-69-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: aq. KOH View Scheme

ethyl 3-ethoxypropionate (763-69-9) + formic acid ethyl ester (109-94-4) → trans-2-Ethoxymethylen-3-ethoxy-propionsaeure-ethylester

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In tetrahydrofuran at 20℃; for 1h; Stage #2: With dimethyl sulfate In tetrahydrofuran at 50℃; for 2h;	100%

ethyl 3-ethoxypropionate (763-69-9) + N-propyl-toluene-4-sulfonamide (1133-12-6) → C15H25NO3S (1391911-31-1)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

ethyl 3-ethoxypropionate (763-69-9) + N-benzyl-p-toluenesulfonamide (1576-37-0) → C19H25NO3S (1391911-32-2)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

ethyl 3-ethoxypropionate (763-69-9) + 4-methyl-N-pentylbenzenesulfonamide (106011-68-1) → C17H29NO3S (1394028-60-4)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

ethyl 3-ethoxypropionate (763-69-9) + 4-methyl-N-(3-methylbut-2-enyl)benzenesulfonamide (78388-19-9) → C17H27NO3S (1394028-61-5)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

ethyl 3-ethoxypropionate (763-69-9) + N-methyl-p-toluenesulfonylamide (640-61-9) → C13H21NO3S (1391911-30-0)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%

ethyl 3-ethoxypropionate (763-69-9) → 3-Ethoxypropionsaeurehydrazid (37952-36-6)

Conditions	Yield
With hydrazine In ethanol; water Reflux;	85%

bromobenzene (108-86-1) + ethyl 3-ethoxypropionate (763-69-9) → 3-ethoxy-1,1-diphenylpropan-1-ol

Conditions	Yield
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; Barbier Coupling Reaction; chemoselective reaction;	83%
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; chemoselective reaction;	83%

ethyl 3-ethoxypropionate (763-69-9) + para-bromotoluene (106-38-7) → 3-ethoxy-1,1-di(p-tolyl)propan-1-ol (1541189-44-9)

Conditions	Yield
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; Barbier Coupling Reaction; chemoselective reaction;	77%
With magnesium; copper(II) oxide In tetrahydrofuran at 65℃; for 4h; chemoselective reaction;	77%

2,3-Diaminopyridine (452-58-4) + ethyl 3-ethoxypropionate (763-69-9) → 2-(2-ethoxyethyl)-3H-imidazo[4,5-b]pyridine (1235235-73-0)

Conditions	Yield
With lithium bromide at 110 - 115℃; for 9h; Neat (no solvent);	75%

ethyl 3-ethoxypropionate (763-69-9) + toluene-4-sulfonamide (70-55-3) → C17H29NO4S (1391911-29-7)

Conditions	Yield
With 1,1,3,3-Tetramethyldisiloxane; (Ace)Ru3(CO)7 In dichloromethane at 20℃; for 20h; Inert atmosphere;	72%

ethyl 3-ethoxypropionate (763-69-9) + 1,2-diamino-benzene (95-54-5) → 2-(2-ethoxy-ethyl)-1H-benzimidazole (51036-80-7)

Conditions	Yield
With lithium bromide at 110 - 115℃; for 10h; Neat (no solvent);	70%
With hydrogenchloride

ethyl 3-ethoxypropionate (763-69-9) + 1,2-dibromomethane (74-95-3) → 1,1-dibromo-4-ethoxy-2-butanone

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h;	67%

morpholine (110-91-8) + ethyl 3-ethoxypropionate (763-69-9) → β-ethoxy-N-morpholinylpropionamide

Conditions	Yield
With iron(II) triflate at 0 - 80℃; under 760.051 Torr; for 1h; Autoclave;	62%

ethyl 3-ethoxypropionate (763-69-9) + dimethyl sulfate (77-78-1) + formic acid ethyl ester (109-94-4) → (Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate (2974-30-3)

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0℃; for 2h; Claisen condensation; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h;	58%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In toluene at 0℃; for 2h; Inert atmosphere; Stage #2: dimethyl sulfate In toluene at 0 - 50℃; for 12h; Inert atmosphere;	52%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 20℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
(i) NaOEt, EtOH, (ii) /BRN= 635994/; Multistep reaction;
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; benzene at 0℃; for 2h; Stage #2: dimethyl sulfate In ethanol; benzene at 50℃; for 3h;

ethyl 3-ethoxypropionate (763-69-9) + formic acid ethyl ester (109-94-4) → (Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; hexane at 0 - 20℃; for 3h; Stage #2: With triethylamine hydrochloride; sodium hydroxide at 20℃; for 4h;	56%

2-bromo-pyridine (109-04-6) + ethyl 3-ethoxypropionate (763-69-9) → 3-ethoxy-1-(pyridin-2-yl)propan-1-one

Conditions	Yield
Stage #1: 2-bromo-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Stage #2: ethyl 3-ethoxypropionate In diethyl ether; hexane at -78℃; for 1h;	54%
Stage #1: 2-bromo-pyridine With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Stage #2: ethyl 3-ethoxypropionate In diethyl ether; hexane at -78℃; for 1h;	54%

ethyl 3-ethoxypropionate (763-69-9) → glyoxylic acid ethyl ester (924-44-7) + 3-oxo-propionic acid ethyl ester (34780-29-5) + acetaldehyde (75-07-0) + 3-Formyloxy-propionic acid ethyl ester + formic acid ethyl ester (109-94-4)

Conditions	Yield
With dodecane; methyl nitrite; nitrogen(II) oxide at 23.9℃; under 760 Torr; Rate constant; Product distribution; Mechanism; Irradiation;	A 25% B 4.8% C 4.9% D 30% E 37%

ethyl 3-ethoxypropionate (763-69-9) + dimethyl sulfate (77-78-1) + formic acid ethyl ester (109-94-4) → (Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate (879008-23-8)

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium In ethanol; hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice; Stage #3: With triethylamine hydrochloride; sodium hydroxide In hexane at 20℃; for 4h;	37%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice;	37%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
Stage #1: ethyl 3-ethoxypropionate; dimethyl sulfate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 50℃; for 5h; Stage #2: With triethylamine hydrochloride; sodium hydroxide In benzene for 4h;	33%
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With sodium ethanolate In hexane at 0 - 20℃; Stage #2: dimethyl sulfate In hexane at 50℃; for 2h; Cooling with ice;

4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (211245-64-6) + ethyl 3-ethoxypropionate (763-69-9) → 8-cyclopentyl-6-ethoxymethyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (571189-94-1)

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate With lithium hexamethyldisilazane In tetrahydrofuran Stage #2: 4-cyclopentylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde In tetrahydrofuran for 24h;	35%
In tetrahydrofuran; ethyl acetate	34.9%

ethyl 3-ethoxypropionate (763-69-9) + dimethyl sulfate (77-78-1) + formic acid ethyl ester (109-94-4) → (z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate

Conditions	Yield
Stage #1: ethyl 3-ethoxypropionate; formic acid ethyl ester With ethanol; sodium In benzene at 0 - 20℃; for 2h; Stage #2: dimethyl sulfate In benzene at 50℃; for 3h; Stage #3: With sodium hydroxide; water; triethylamine hydrochloride In benzene for 4h;	33%

Upstream product

• 57-57-8 β-Propiolactone 
• 64-17-5 ethanol 
• 539-74-2 Ethyl 3-bromopropionate 
• 141-52-6 sodium ethanolate 
• 6414-69-3 ethyl 3-iodopropanoate 
• 623-71-2 ethyl 3-chloropropanoate 
• 2141-62-0 3-(ethoxy)propionitrile 
• 140-88-5 ethyl acrylate 
• 462-95-3 formaldehyde diethyl acetal 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 22409-91-2 3-phenoxypropionic acid ethyl ester 
• 78097-85-5 ethyl 2-bromo-3-ethoxypropanoate 
• 78-94-4 methyl vinyl ketone 
• 83747-24-4 2-(2'-Ethoxycarbonylethyl)-saccharin 

Downstream Products

• 14144-41-3 β-Propoxy-propionsaeure-propylester 
• 140-88-5 ethyl acrylate 
• 111-35-3 3-ethoxy-1-propanol 
• 4324-38-3 3-ethoxypropanoic acid 
• 30354-97-3 6-(2-ethoxy-ethyl)-[1,3,5]triazine-2,4-diyldiamine 
• 51036-80-7 2-(2-ethoxy-ethyl)-1H-benzimidazole 
• 924-44-7 glyoxylic acid ethyl ester 
• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 75-07-0 acetaldehyde 
• 109-94-4 formic acid ethyl ester 
• 57401-76-0 2-aminopyrimidine-5-carboxylic acid ethyl ester 
• 89793-12-4 ethyl 2-chloropyrimidine-5-carboxylate 
• 95928-49-7 ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate 
• 304431-55-8 ethyl 2-[N-(3,5-di-tert-butylphenyl)amino] pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Synthesis method of ethyl 3-ethoxypropionate

The invention relates to a synthesis method of ethyl 3-ethoxypropionate, which comprises the following steps of carrying out addition reaction on absolute ethyl alcohol and ethyl acrylate in the presence of a catalyst which is a micromolecular tertiary amine catalyst, after the reaction is finished, removing excessive absolute ethyl alcohol, unreacted ethyl acrylate and the catalyst through rectification, collecting ethyl 3-ethoxypropionate with the purity being greater than 99.8% as a product, and recycling the collected excessive absolute ethyl alcohol, unreacted ethyl acrylate and the catalyst in the next reaction. The synthesis method has the advantages of simple synthesis, mild conditions, no need of acid neutralization, few side reactions, no three wastes, high conversion rate, long-term use of the catalyst, repeated cyclic utilization, no damage, simplified separation process, good product quality, easy obtainment of 99.8% or above of purity, promotion of large-scale production,and facilitation of large-scale application to the photoelectric industry.

One-pot production of diethyl maleate via catalytic conversion of raw lignocellulosic biomass

The conversion of lignocellulose into a value-added chemical with high selectivity is of great significance but is a big challenge due to the structural diversities of biomass components. Here, we have reported an efficient approach for the one-step conversion of raw lignocellulose into diethyl maleate by the polyoxometalate ionic liquid [BSmim]CuPW12O40 in ethanol under mild conditions. The results reveal that all of the fractions in biomass, i.e., cellulose, lignin and hemicellulose, were simultaneously converted into diethyl maleate (DEM), achieving a 329.6 mg g-1 yield and 70.3% selectivity from corn stalk. Importantly, the performance of the ionic liquid catalyst [BSmim]CuPW12O40 was nearly twice that of CuHPW12O40, which can be attributed to the lower incorporation of the Cu2+ site in [BSmim]CuPW12O40. Hence, this process opens a promising route for producing bio-based bulk chemicals from raw lignocellulose without any pretreatment.

Method for producing Alkyl 3-Alkoxypropionate Using Continuous Type Process

The invention relates to a process for preparing alkyl 3 - alkoxypropionates. More particularly, it relates to a continuous process for preparing ethyl 3 - ethoxypropionate. A method for preparing an alkyl 3 - alkoxypropionate for a semiconductor is provided to produce alkyl 3 - alkoxypropionate for a semiconductor on a large scale using a continuous reaction, and to prepare an alkyl 3 - 3 - alkoxypropionate for a semiconductor in a large scale production process using a continuous method.

Method for producing Ethyl 3-Ethoxypropionate

The present invention relates to a method for manufacturing ethyl 3-ethoxypropionate (EEP), comprising a step of synthesizing EEP with an ethyl acrylate monomer and ethanol in the presence of a catalyst, and then efficiently regenerating unreacted ethanol and the ethyl acrylate monomer from a reaction product obtained by removing a salt. It is possible to increase economic feasibility of EEP by efficiently regenerating and reusing, especially, ethanol among reaction products.COPYRIGHT KIPO 2019

Method for Producing Alkyl 3-Alkoxy Propionate

The present invention relates to a method for manufacturing alkyl 3-alkoxypropionate. The present invention relates to a method for manufacturing alkoxypropionate which can increase the conversion rate by controlling the water content in a reaction mixture. The method comprises the steps of: preparing a first mixture; producing a second mixture; heating the second mixture; producing a third mixture; analyzing the conversion rate; and adding water to the third mixture when the conversion rate is less than 97 wt%.(AA) Signal 1(BB) Retention time display [min](CC) Area [uV*sec](DD) Height [uV](EE) Area% component name [%](FF) Unidentified component 1(GG) Unidentified component 2(HH) Unidentified component 3(II) Unidentified component 4(JJ) Unidentified component 5(KK) Unidentified component 6(LL) Unidentified component 7COPYRIGHT KIPO 2020

Method for Refining Alkyl 3-Alkoxy Propionate

The present invention relates to a method for refining alkyl 3-alkoxy propionate, and more particularly, to a method for refining ethyl 3-ethoxypropionate. According to the method for refining alkyl 3-alkoxy propionate according to the present invention, by continuously refining a reaction production liquid, in which an alkyl 3-alkoxy propionate synthesis reaction using a strong base catalyst is completed, with a high purity by fractional distillation without a neutralization process, it is possible to produce alkyl 3-alkoxy propionate with good solubility that can be used in a semiconductor manufacturing process.(AA) Low boiling organic matter(BB) Low boiling point impurity(CC) Alkyl 3-alkoxy propionate(DD) Moisture-added reaction product(EE) First distillation column(FF) Second distillation column(GG) Third distillation column(HH) High boiling point impurities and nonvolatile ionic impurities(II) Alkyl 3-alkoxy propionate containing mixture(JJ) High boiling point impurityCOPYRIGHT KIPO 2020

MANUFACTURING METHOD OF N-SUBSTITUTED (METH)ACRYLAMIDE

To provide a method for industrially manufacturing high purity β-alkoxypropionic acid amide, β-aminopropionic acid amide and N-substituted (meth)acrylamide at high yield using (meth)acrylic acid ester as a starting material.SOLUTION: By conducting an amidation reaction with amine in the presence of a metal complex as a catalyst using β-substituted propionic acid ester which is a product material of a Michael addition reaction of (meth)acrylic acid ester and alcohol or amine, β-substituted propionic acid amide is obtained. Further by conducting a thermal decomposition reaction of the β-substituted propionic acid amide in the presence of the metal complex, and eliminating the alcohol or the amine, objective compound N-substituted (meth)acrylamide is obtained.SELECTED DRAWING: None

METHOD FOR PRODUCING β-ALKOXYPROPIONIC ACID ESTER

PROBLEM TO BE SOLVED: To provide a method for producing β-alkoxypropionic acid ester, which enables efficient and easy recovery of a product from a reaction mixture obtained by using an alkali metal alkoxide or an alkaline earth metal alkoxide as a catalyst. SOLUTION: The method for producing a β-alkoxypropionic acid ester comprises reacting an alkyl acrylate and alcohols in the presence of an alkali metal or alkaline earth metal alkoxide as a catalyst. After completion of the reaction, a compound which neutralizes the alkali metal or alkaline earth metal alkoxide is added to the reaction mixture, followed by distillation. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Ethyl 3-ethoxypropionate preparation method

The invention discloses an ethyl 3-ethoxypropionate preparation method, wherein the raw materials comprise anhydrous ethanol and ethyl acrylate, and the catalyst is ethyl acrylate accounting for 0.1-20% of the weight. According to the present invention, the method has advantages of simple synthesis, mild conditions, less side reactions, substantially-simplified separation process, convenient continuous production and the like, wherein the catalyst can be recycled without the damage, and can be regenerated.

MANUFACTURING METHOD OF β-SUBSTITUTED PROPIONIC ACID AMIDE AND N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing β-alkoxy propionic acid amide, β-amino propionic acid amide and N-substituted (meth)acryl amide using (meth)acrylic acid ester as starting material at high yield and high purity. SOLUTION: There is provided a method for obtaining N-substituted (meth)acryl amide represented by target compound formula (7) by conducting an amidation reaction with amine using β-substituted propionic acid ester represented by the formula (1) of a product of a Michael addition reaction of (meth)acrylic acid ester and alcohol or amine in presence of a metal complex as a catalyst to obtain β-substituted propionic acid amide represented by the formula (3) and conducting a thermal decomposition reaction of β-substituted propionic acid amide in presence of the metal complex as the catalyst to eliminate alcohol or amine. A-CH2-C(R1)H-C(=O)-OR2 (1), A-CH2-C(R1)H-C(=O)-N(R3)R4 (3), CH2=C(R1)-C(=O)-N(R3)R4 (7) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT