3346-61-0

Usage

InChI:InChI=1/C6H8N4O4/c1-8-4(7)3(10(13)14)5(11)9(2)6(8)12/h7H2,1-2H3

Upstream product

• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 
• 183987-67-9 4,6-dimethyl-1-oxy-4H-[1,2,5]selenadiazolo[3,4-d]pyrimidine-5,7-dione 
• 183987-66-8 4,6-dimethyl-1-oxy-4H-[1,2,5]thiadiazolo[3,4-d]pyrimidine-5,7-dione 

Downstream Products

• 595558-86-4 5-(3,5-di-tert-butyl-4-hydroxyphenylcarboxamido)-1-(4-fluorophenyl)-3-methyl-6-methylamino-2,4-(1H,3H)-pyrimidinedione 
• 595558-79-5 6-amino-5-(3,5-di-tert-butyl-4-hydroxyphenylcarboxamido)-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione 
• 595559-18-5 5-amino-1-(4-fluoro-phenyl)-3-methyl-6-methylamino-1H-pyrimidine-2,4-dione 
• 595559-16-3 1-(4-fluoro-phenyl)-3-methyl-6-methylamino-5-nitroso-1H-pyrimidine-2,4-dione 
• 595559-14-1 1-(4-fluorophenyl)-3-methyl-6-methylamino-2,4-(1H,3H)-pyrimidinedione 
• 944-73-0 1,3-dimethyluric acid 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 42963-36-0 4,6-dimethyl-<1,2,5>oxadiazolo<3,4-d>pyrimidine-5,7(4H,6H)-dione 1-oxide 

Relevant academic research and scientific papers

Extraction of radio-labelled xanthine derivatives by artificial receptors: Deep insight into the association behaviour

Association constants for the interaction of almost insoluble substrates with triphenylene ketal-based receptors in toluene have been determined by means of an extraction method employing the corresponding radio-labelled substrates. Flexible and more polar receptors tend to aggregate and exhibit inferior extraction qualities. Binding constants in toluene were found to be in the range 105-107 M-1, which is significantly higher than in dichloromethane. X-ray analyses indicate the direct participation of a water molecule in the binding process, which may account for the surprisingly small effect of moisture in the solvent on the stability of the complexes.

Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction.

In order to obtain novel topically applied anti-inflammatory compounds containing an inexpensive anti-oxidative moiety without chirality, we synthesized compound 2c derivatives having a di-tert-butylphenol moiety, and evaluated by topical administration their anti-inflammatory potentials on picryl chloride-(PC) induced contact hypersensitivity reaction (CHR) in mice. In the course of our structure-activity relationship (SAR) studies on the pyrimidine or the anti-oxidative moiety and the linker between them, the most potent compounds (10, 11) were obtained by the insertion of a C2 unit in compound 2c. The potencies of these compounds were 2-fold greater than that of 1. Compounds 10 and 11 were considered to be useful lead compounds having inexpensive anti-oxidative moieties without chirality.